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mtnP protein (Mycobacterium smegmatis) - STRING interaction network
"mtnP" - 5'-methylthioadenosine phosphorylase in Mycobacterium smegmatis
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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mtnP5’-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5’- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (259 aa)    
Predicted Functional Partners:
galE3
NAD-dependent epimerase/dehydratase (346 aa)
   
        0.905
add
Adenosine deaminase (366 aa)
   
 
  0.863
MSMEG_0989
Hypothetical protein (81 aa)
              0.859
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (180 aa)
   
 
  0.844
adoK
Adenosine kinase (325 aa)
   
  0.796
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP (520 aa)
   
 
  0.786
MSMEG_6803
Ribose transporter permease RbsC (339 aa)
           
  0.761
MSMEG_6802
ABC transporter ATP-binding protein (263 aa)
           
  0.761
fprB
ferredoxin/ferredoxin--NADP reductase (557 aa)
   
 
  0.753
mtnN
MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5’-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5’-methylthioribose and S-ribosylhomocysteine, respectively (250 aa)
       
  0.715
Your Current Organism:
Mycobacterium smegmatis
NCBI taxonomy Id: 246196
Other names: Bacillus smegmatis, Bacterium smegmatis, M. smegmatis, M. smegmatis str. MC2 155, Mycobacterium paratuberculosis smegmatis, Mycobacterium smegmatis, Mycobacterium smegmatis MC2 155, Mycobacterium smegmatis str. MC2 155, Mycobacterium smegmatis strain MC2 155
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