node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK72851.1 | ABK72905.1 | MSMEG_3080 | MSMEG_3079 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Conserved hypothetical protein; Displays ATPase and GTPase activities. | 0.969 |
ABK72851.1 | uvrC | MSMEG_3080 | MSMEG_3078 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.798 |
ABK72851.1 | whiA | MSMEG_3080 | MSMEG_3081 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Conserved hypothetical protein; Involved in cell division and chromosome segregation. | 0.968 |
ABK72905.1 | ABK72851.1 | MSMEG_3079 | MSMEG_3080 | Conserved hypothetical protein; Displays ATPase and GTPase activities. | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.969 |
ABK72905.1 | uvrC | MSMEG_3079 | MSMEG_3078 | Conserved hypothetical protein; Displays ATPase and GTPase activities. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.798 |
ABK72905.1 | whiA | MSMEG_3079 | MSMEG_3081 | Conserved hypothetical protein; Displays ATPase and GTPase activities. | Conserved hypothetical protein; Involved in cell division and chromosome segregation. | 0.954 |
lexA | pcrA | MSMEG_2740 | MSMEG_5534 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | 0.704 |
lexA | ruvA | MSMEG_2740 | MSMEG_2944 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.873 |
lexA | ruvB | MSMEG_2740 | MSMEG_2945 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.671 |
lexA | uvrA | MSMEG_2740 | MSMEG_3808 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.725 |
lexA | uvrA-2 | MSMEG_2740 | MSMEG_6806 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC, A subunit; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR00630. | 0.729 |
lexA | uvrB | MSMEG_2740 | MSMEG_3816 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.709 |
lexA | uvrC | MSMEG_2740 | MSMEG_3078 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.830 |
pcrA | lexA | MSMEG_5534 | MSMEG_2740 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.704 |
pcrA | ruvA | MSMEG_5534 | MSMEG_2944 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.522 |
pcrA | ruvB | MSMEG_5534 | MSMEG_2945 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.719 |
pcrA | uvrA | MSMEG_5534 | MSMEG_3808 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.930 |
pcrA | uvrA-2 | MSMEG_5534 | MSMEG_6806 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | Excinuclease ABC, A subunit; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR00630. | 0.783 |
pcrA | uvrB | MSMEG_5534 | MSMEG_3816 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.971 |
pcrA | uvrC | MSMEG_5534 | MSMEG_3078 | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.874 |