node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70095.1 | ABK72219.1 | MSMEG_2778 | MSMEG_2763 | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | Conserved hypothetical protein. | 0.677 |
ABK70095.1 | ABK73778.1 | MSMEG_2778 | MSMEG_5328 | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | Conserved hypothetical protein. | 0.658 |
ABK70095.1 | ABK74795.1 | MSMEG_2778 | MSMEG_3644 | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | Transcriptional regulator, MerR family protein. | 0.594 |
ABK70095.1 | glnE | MSMEG_2778 | MSMEG_4293 | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.713 |
ABK70095.1 | rbpA | MSMEG_2778 | MSMEG_3858 | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB). | 0.577 |
ABK72219.1 | ABK70095.1 | MSMEG_2763 | MSMEG_2778 | Conserved hypothetical protein. | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | 0.677 |
ABK72219.1 | ABK73069.1 | MSMEG_2763 | MSMEG_4287 | Conserved hypothetical protein. | Integral membrane protein. | 0.707 |
ABK72219.1 | ABK74795.1 | MSMEG_2763 | MSMEG_3644 | Conserved hypothetical protein. | Transcriptional regulator, MerR family protein. | 0.790 |
ABK72219.1 | glnE | MSMEG_2763 | MSMEG_4293 | Conserved hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.721 |
ABK72219.1 | rbpA | MSMEG_2763 | MSMEG_3858 | Conserved hypothetical protein. | Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB). | 0.778 |
ABK73069.1 | ABK72219.1 | MSMEG_4287 | MSMEG_2763 | Integral membrane protein. | Conserved hypothetical protein. | 0.707 |
ABK73069.1 | ABK73778.1 | MSMEG_4287 | MSMEG_5328 | Integral membrane protein. | Conserved hypothetical protein. | 0.745 |
ABK73069.1 | ABK74795.1 | MSMEG_4287 | MSMEG_3644 | Integral membrane protein. | Transcriptional regulator, MerR family protein. | 0.745 |
ABK73069.1 | glnE | MSMEG_4287 | MSMEG_4293 | Integral membrane protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.685 |
ABK73069.1 | rbpA | MSMEG_4287 | MSMEG_3858 | Integral membrane protein. | Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB). | 0.750 |
ABK73082.1 | glnA-2 | MSMEG_2426 | MSMEG_4290 | Nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543; Belongs to the P(II) protein family. | Glutamine synthetase, type I; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. | 0.934 |
ABK73082.1 | glnA-3 | MSMEG_2426 | MSMEG_4294 | Nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543; Belongs to the P(II) protein family. | Glutamine synthetase, type I; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation [...] | 0.839 |
ABK73082.1 | glnD | MSMEG_2426 | MSMEG_2427 | Nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543; Belongs to the P(II) protein family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.999 |
ABK73082.1 | glnE | MSMEG_2426 | MSMEG_4293 | Nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543; Belongs to the P(II) protein family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.782 |
ABK73778.1 | ABK70095.1 | MSMEG_5328 | MSMEG_2778 | Conserved hypothetical protein. | Identified by match to protein family HMM PF00570; match to protein family HMM PF01612. | 0.658 |