STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kstR2Transcriptional regulator, TetR family protein; Controls the expression of a small regulon that may play a role in the utilization of cholesterol. (205 aa)    
Predicted Functional Partners:
kstR
Transcriptional regulator, TetR family protein; Controls the expression of genes used for utilizing diverse lipids as energy sources.
  
  
 0.957
ABK72416.1
acetyl-CoA acetyltransferase; Identified by match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; Belongs to the thiolase-like superfamily. Thiolase family.
  
  
 0.947
ABK74969.1
enoyl-CoA hydratase; Identified by match to protein family HMM PF00378.
 
  
 0.920
ABK75352.1
Short chain dehydrogenase; Identified by match to protein family HMM PF00106.
 
  
 0.906
kshA
Rieske [2Fe-2S] domain protein; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.
  
  
 0.883
ABK71994.1
Putative acyl-CoA dehydrogenase; Identified by match to protein family HMM PF00441; match to protein family HMM PF02770.
 
  
 0.858
ABK70424.1
Short chain dehydrogenase; Identified by match to protein family HMM PF00106; match to protein family HMM PF01370.
 
   
 0.854
ABK73022.1
Coenzyme A transferase, subunit A; Identified by match to protein family HMM PF01144.
  
   
 0.786
cyp142
P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
      
 0.781
ksdD
3-ketosteroid dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to.
  
  
 0.777
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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