node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71897.1 | egtA | MSMEG_1226 | MSMEG_6250 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.735 |
ABK71897.1 | egtB | MSMEG_1226 | MSMEG_6249 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | 0.499 |
ABK71897.1 | egtC | MSMEG_1226 | MSMEG_6248 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.405 |
ABK71897.1 | egtD | MSMEG_1226 | MSMEG_6247 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.926 |
ABK71897.1 | egtE | MSMEG_1226 | MSMEG_6246 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.808 |
ABK72529.1 | egtD | MSMEG_3148 | MSMEG_6247 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.779 |
ABK72529.1 | purD | MSMEG_3148 | MSMEG_5852 | Conserved hypothetical protein. | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. | 0.786 |
ABK75199.1 | egtA | MSMEG_1452 | MSMEG_6250 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.739 |
ABK75199.1 | egtB | MSMEG_1452 | MSMEG_6249 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | 0.507 |
ABK75199.1 | egtC | MSMEG_1452 | MSMEG_6248 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.405 |
ABK75199.1 | egtD | MSMEG_1452 | MSMEG_6247 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.927 |
ABK75199.1 | egtE | MSMEG_1452 | MSMEG_6246 | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.808 |
egtA | ABK71897.1 | MSMEG_6250 | MSMEG_1226 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | 0.735 |
egtA | ABK75199.1 | MSMEG_6250 | MSMEG_1452 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | 0.739 |
egtA | egtB | MSMEG_6250 | MSMEG_6249 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | 0.998 |
egtA | egtC | MSMEG_6250 | MSMEG_6248 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.986 |
egtA | egtD | MSMEG_6250 | MSMEG_6247 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.995 |
egtA | egtE | MSMEG_6250 | MSMEG_6246 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.989 |
egtA | hutH | MSMEG_6250 | MSMEG_1183 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | Histidine ammonia-lyase; Identified by similarity to EGAD:14121; match to protein family HMM PF00221; match to protein family HMM TIGR01225. | 0.610 |
egtB | ABK71897.1 | MSMEG_6249 | MSMEG_1226 | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. | 0.499 |