node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69525.1 | ABK75515.1 | MSMEG_6252 | MSMEG_6251 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.796 |
ABK69525.1 | egtA | MSMEG_6252 | MSMEG_6250 | Conserved hypothetical protein. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.533 |
ABK69525.1 | egtB | MSMEG_6252 | MSMEG_6249 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | 0.533 |
ABK69525.1 | egtC | MSMEG_6252 | MSMEG_6248 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.556 |
ABK69525.1 | egtD | MSMEG_6252 | MSMEG_6247 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.555 |
ABK69525.1 | egtE | MSMEG_6252 | MSMEG_6246 | Conserved hypothetical protein. | Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.558 |
ABK70200.1 | egtC | MSMEG_6234 | MSMEG_6248 | CBS domain pair protein. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.408 |
ABK70200.1 | egtD | MSMEG_6234 | MSMEG_6247 | CBS domain pair protein. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.452 |
ABK71220.1 | egtA | MSMEG_1803 | MSMEG_6250 | RsbW protein. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.487 |
ABK71220.1 | egtC | MSMEG_1803 | MSMEG_6248 | RsbW protein. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.480 |
ABK71409.1 | egtA | MSMEG_6245 | MSMEG_6250 | Chloramphenicol resistance protein; Identified by match to protein family HMM PF06779; match to protein family HMM PF07690. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.477 |
ABK71409.1 | egtB | MSMEG_6245 | MSMEG_6249 | Chloramphenicol resistance protein; Identified by match to protein family HMM PF06779; match to protein family HMM PF07690. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | 0.496 |
ABK71409.1 | egtC | MSMEG_6245 | MSMEG_6248 | Chloramphenicol resistance protein; Identified by match to protein family HMM PF06779; match to protein family HMM PF07690. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.445 |
ABK71409.1 | egtD | MSMEG_6245 | MSMEG_6247 | Chloramphenicol resistance protein; Identified by match to protein family HMM PF06779; match to protein family HMM PF07690. | Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate. | 0.450 |
ABK71409.1 | egtE | MSMEG_6245 | MSMEG_6246 | Chloramphenicol resistance protein; Identified by match to protein family HMM PF06779; match to protein family HMM PF07690. | Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.456 |
ABK72749.1 | egtA | MSMEG_6255 | MSMEG_6250 | Conserved hypothetical protein. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.478 |
ABK72749.1 | egtC | MSMEG_6255 | MSMEG_6248 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.439 |
ABK75515.1 | ABK69525.1 | MSMEG_6251 | MSMEG_6252 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.796 |
ABK75515.1 | egtA | MSMEG_6251 | MSMEG_6250 | Conserved hypothetical protein. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine. | 0.570 |
ABK75515.1 | egtB | MSMEG_6251 | MSMEG_6249 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. | 0.558 |