node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69675.1 | ethR | MSMEG_5753 | MSMEG_6441 | Serine/threonine specific protein phosphatase; Identified by match to protein family HMM PF00149. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.762 |
ABK72606.1 | ABK74448.1 | MSMEG_5424 | MSMEG_0548 | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | 0.713 |
ABK72606.1 | ABK75689.1 | MSMEG_5424 | MSMEG_2043 | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | 0.706 |
ABK72606.1 | ethR | MSMEG_5424 | MSMEG_6441 | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.680 |
ABK74268.1 | ABK74448.1 | MSMEG_0120 | MSMEG_0548 | Probable transcriptional regulatory protein; Identified by match to protein family HMM PF00440. | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | 0.583 |
ABK74268.1 | ethR | MSMEG_0120 | MSMEG_6441 | Probable transcriptional regulatory protein; Identified by match to protein family HMM PF00440. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.774 |
ABK74268.1 | kstR2 | MSMEG_0120 | MSMEG_6009 | Probable transcriptional regulatory protein; Identified by match to protein family HMM PF00440. | Transcriptional regulator, TetR family protein; Controls the expression of a small regulon that may play a role in the utilization of cholesterol. | 0.696 |
ABK74448.1 | ABK72606.1 | MSMEG_0548 | MSMEG_5424 | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | 0.713 |
ABK74448.1 | ABK74268.1 | MSMEG_0548 | MSMEG_0120 | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | Probable transcriptional regulatory protein; Identified by match to protein family HMM PF00440. | 0.583 |
ABK74448.1 | ABK75689.1 | MSMEG_0548 | MSMEG_2043 | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | 0.736 |
ABK74448.1 | ethR | MSMEG_0548 | MSMEG_6441 | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.720 |
ABK75689.1 | ABK72606.1 | MSMEG_2043 | MSMEG_5424 | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | 0.706 |
ABK75689.1 | ABK74448.1 | MSMEG_2043 | MSMEG_0548 | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | Chromosome replication initiation inhibitor protein; Identified by match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family. | 0.736 |
ABK75689.1 | ethR | MSMEG_2043 | MSMEG_6441 | Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.706 |
dinP | ethA | MSMEG_6443 | MSMEG_6440 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Monooxygenase, flavin-binding family protein; Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones (2-hexanone to 2- dodecanone) and on aromatic ketones (phenylacetone and benzylacetone). Is also able to catalyze enantioselective sulfoxidation of methyl-p- tolylsulfide. In vivo, likely functions as a BVMO, but the exact nature of the physiological substrate(s) remains to be established. | 0.605 |
dinP | ethR | MSMEG_6443 | MSMEG_6441 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.840 |
ethA | dinP | MSMEG_6440 | MSMEG_6443 | Monooxygenase, flavin-binding family protein; Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones (2-hexanone to 2- dodecanone) and on aromatic ketones (phenylacetone and benzylacetone). Is also able to catalyze enantioselective sulfoxidation of methyl-p- tolylsulfide. In vivo, likely functions as a BVMO, but the exact nature of the physiological substrate(s) remains to be established. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.605 |
ethA | ethR | MSMEG_6440 | MSMEG_6441 | Monooxygenase, flavin-binding family protein; Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones (2-hexanone to 2- dodecanone) and on aromatic ketones (phenylacetone and benzylacetone). Is also able to catalyze enantioselective sulfoxidation of methyl-p- tolylsulfide. In vivo, likely functions as a BVMO, but the exact nature of the physiological substrate(s) remains to be established. | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | 0.869 |
ethA | inhA | MSMEG_6440 | MSMEG_3151 | Monooxygenase, flavin-binding family protein; Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones (2-hexanone to 2- dodecanone) and on aromatic ketones (phenylacetone and benzylacetone). Is also able to catalyze enantioselective sulfoxidation of methyl-p- tolylsulfide. In vivo, likely functions as a BVMO, but the exact nature of the physiological substrate(s) remains to be established. | [NADH] enoyl-[acyl-carrier-protein] reductase; Enoyl-ACP reductase of the type II fatty acid syntase (FAS- II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the double bond of 2-trans- enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway. Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates (By similarity). The mycobacterial FAS-II system utilizes th [...] | 0.465 |
ethR | ABK69675.1 | MSMEG_6441 | MSMEG_5753 | Transcriptional regulator, TetR family protein; Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). | Serine/threonine specific protein phosphatase; Identified by match to protein family HMM PF00149. | 0.762 |