STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mspBPorin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. (215 aa)    
Predicted Functional Partners:
ABK71747.1
ZbpA protein; Identified by match to protein family HMM PF01575.
   
  
 0.593
ABK71183.1
Conserved hypothetical protein.
   
  
 0.591
ABK70588.1
Conserved hypothetical protein.
   
  
 0.591
ABK74785.1
Identified by match to protein family HMM PF00903.
   
  
 0.591
mspC
Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family.
   
 
0.554
mspD
MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion.
   
 
0.553
mspA
Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...]
   
 
0.551
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
  
 0.478
ABK71059.1
Conserved hypothetical protein.
  
    0.472
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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