STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phnFGntR-family protein transcriptional regulator; Represses the phnDCE operon, involved in the uptake of phosphate, under conditions of phosphate availability in the cell. (250 aa)    
Predicted Functional Partners:
phnD
Phosphonate-binding periplasmic protein; Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for phosphate binding. Belongs to the phosphate/phosphite/phosphonate binding protein family.
 
  
 0.946
phnC
Phosphonate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for energy coupling to the transport system.
  
  
 0.941
phnE
Putative transporter; Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.929
pstS
Phosphate ABC transporter, phosphate-binding protein PstS; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family.
  
  
 0.619
senX3
Sensor histidine kinase SenX3; Part of the two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 under conditions of phosphate limitation. Probably does not itself sense phosphate concentrations, which may be relayed to SenX3 by the PstSCAB phosphate transporter system.
  
  
 0.597
ABK74482.1
PTS system, glucose-specific IIBC component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826.
 
  
 0.593
nagA
N-acetylglucosamine-6-phosphate deacetylase; Identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221.
 
  
 0.545
ABK71703.1
Putative conserved exported protein.
  
    0.528
ABK74597.1
Transcriptional regulator; Identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350.
  
  
 0.503
regX3
DNA-binding response regulator RegX3; Part of the two-component regulatory system SenX3/RegX3. Once phosphorylated by SenX3, activates the expression of several operons/genes involved in phosphate assimilation and metabolism, such as pstSCAB, phnDCE, and phoA.
   
  
 0.488
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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