STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknGSerine/threonine protein kinase; Identified by match to protein family HMM PF00069; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (760 aa)    
Predicted Functional Partners:
garA
Forkhead-associated protein; Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd and Gdh.
 
 
 0.998
ABK71181.1
Bacterial extracellular solute-binding protein, family protein 3; Identified by match to protein family HMM PF00497.
 
  
 0.996
ABK73037.1
Putative conserved membrane protein.
 
  
 0.990
pknB
Serine-threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins (By similarity). Probably phosphorylates RseA.
 
 
0.859
ABK72306.1
Protein phosphatase 2C; Identified by match to protein family HMM PF00481.
 
 
 0.813
murC
UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
  
  
 0.810
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
  
 0.781
ABK75725.1
Serine/threonine protein kinase; Identified by match to protein family HMM PF00069.
  
  
0.778
ABK70127.1
Probable serine/threonine-protein kinase PknB; Identified by match to protein family HMM PF00069; match to protein family HMM PF01163.
  
   
 0.769
ABK75945.1
Identified by match to protein family HMM PF00481.
 
 
 0.766
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (30%) [HD]