STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
senX3Sensor histidine kinase SenX3; Part of the two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 under conditions of phosphate limitation. Probably does not itself sense phosphate concentrations, which may be relayed to SenX3 by the PstSCAB phosphate transporter system. (384 aa)    
Predicted Functional Partners:
regX3
DNA-binding response regulator RegX3; Part of the two-component regulatory system SenX3/RegX3. Once phosphorylated by SenX3, activates the expression of several operons/genes involved in phosphate assimilation and metabolism, such as pstSCAB, phnDCE, and phoA.
 0.999
mtrA
DNA-binding response regulator MtrA; Member of the two-component regulatory system MtrA/MtrB, responding to environmental signals (Probable). Controls expression of a number of genes including dnaA, ripA, fbpB and probably itself. Probably plays a role in cell division.
 
 0.963
mprA
DNA-binding response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).
 
 0.957
ABK72654.1
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.951
phoP
DNA-binding response regulator PhoP; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.951
prrA
DNA-binding response regulator PrrA; Identified by similarity to SP:Q10531; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.941
resD
DNA-binding response regulator ResD; Identified by similarity to SP:P35163; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.918
ABK72873.1
Two component response transcriptional regulatory protein prra; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.901
ABK73706.1
DNA-binding response regulator, PhoP family protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.890
ABK74820.1
KDP operon transcriptional regulatory protein KdpE; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.873
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.