STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vapBProbable ribbon-helix-helix transcription factor, family protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon overexpression neutralizes the effect of overexpressed cognate toxin VapC. Overexpression alone prevents cells from entering a nonculturable dormant state, probably as it binds endogenous VapC. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic rea [...] (84 aa)    
Predicted Functional Partners:
vapC
PIN domain protein; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease, cleavage occurs after the first AU in the consensus sequence AUA(U/A); RNA secondary structure is probably important in substrate choice. Cuts in 5' and 3' UTRs. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. When overexpressed inhibits cell growth, [...]
 
 
 0.999
ABK70239.1
Hypothetical cytosolic protein.
 
   
 0.950
mazE
Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin MazF. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
  
  
 0.884
doc
Death-on-curing protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon overexpression causes bacteriostasis. Its effect is neutralized by coexpression with cognate antitoxin PhD. May bind the 30S ribosomal subunit. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
  
  
 0.809
ABK75566.1
Identified by match to protein family HMM PF02810; match to protein family HMM PF07721.
 
    0.724
ABK71227.1
Conserved hypothetical protein.
  
    0.714
ABK74567.1
Hypothetical cytosolic protein.
  
    0.713
ABK71736.1
Conserved hypothetical protein.
  
    0.713
phd
Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the bacteriostatic effect of cognate toxin Doc. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
     
 0.647
ABK76080.1
Probable conserved transmembrane protein; Identified by match to protein family HMM PF04600; match to protein family HMM TIGR02958.
  
    0.614
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.