node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70406.1 | cofD | MSMEG_1827 | MSMEG_1830 | Hydrolase, nudix family protein, putative; Identified by match to protein family HMM PF00293. | Lppg:fo 2-phospho-l-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.896 |
ABK70406.1 | fbiB | MSMEG_1827 | MSMEG_1829 | Hydrolase, nudix family protein, putative; Identified by match to protein family HMM PF00293. | F420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] | 0.951 |
ABK71916.1 | ABK72261.1 | MSMEG_5998 | MSMEG_0702 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | Monooxygenase; Identified by match to protein family HMM PF00296. | 0.771 |
ABK71916.1 | ABK72942.1 | MSMEG_5998 | MSMEG_5732 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | Monooxygenase; Identified by match to protein family HMM PF00296. | 0.590 |
ABK71916.1 | ABK75024.1 | MSMEG_5998 | MSMEG_1566 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | Oxidoreductase; Identified by match to protein family HMM PF00296. | 0.756 |
ABK71916.1 | ABK75053.1 | MSMEG_5998 | MSMEG_6602 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | Oxidoreductase; Identified by match to protein family HMM PF00296. | 0.734 |
ABK71916.1 | FbiC | MSMEG_5998 | MSMEG_5126 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | FO synthase; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR00423. | 0.876 |
ABK71916.1 | cofD | MSMEG_5998 | MSMEG_1830 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | Lppg:fo 2-phospho-l-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.930 |
ABK71916.1 | fbiB | MSMEG_5998 | MSMEG_1829 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | F420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] | 0.911 |
ABK71916.1 | fbiD | MSMEG_5998 | MSMEG_2392 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.772 |
ABK71916.1 | fgd | MSMEG_5998 | MSMEG_0777 | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Cannot use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6- phosphate or D-fructose-6-phosphate as substrate. Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family. | 0.987 |
ABK72261.1 | ABK71916.1 | MSMEG_0702 | MSMEG_5998 | Monooxygenase; Identified by match to protein family HMM PF00296. | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | 0.771 |
ABK72261.1 | ABK72942.1 | MSMEG_0702 | MSMEG_5732 | Monooxygenase; Identified by match to protein family HMM PF00296. | Monooxygenase; Identified by match to protein family HMM PF00296. | 0.717 |
ABK72261.1 | ABK75053.1 | MSMEG_0702 | MSMEG_6602 | Monooxygenase; Identified by match to protein family HMM PF00296. | Oxidoreductase; Identified by match to protein family HMM PF00296. | 0.648 |
ABK72261.1 | FbiC | MSMEG_0702 | MSMEG_5126 | Monooxygenase; Identified by match to protein family HMM PF00296. | FO synthase; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR00423. | 0.563 |
ABK72261.1 | cofD | MSMEG_0702 | MSMEG_1830 | Monooxygenase; Identified by match to protein family HMM PF00296. | Lppg:fo 2-phospho-l-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.770 |
ABK72261.1 | fbiB | MSMEG_0702 | MSMEG_1829 | Monooxygenase; Identified by match to protein family HMM PF00296. | F420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] | 0.870 |
ABK72261.1 | fbiD | MSMEG_0702 | MSMEG_2392 | Monooxygenase; Identified by match to protein family HMM PF00296. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.771 |
ABK72261.1 | fgd | MSMEG_0702 | MSMEG_0777 | Monooxygenase; Identified by match to protein family HMM PF00296. | F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Cannot use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6- phosphate or D-fructose-6-phosphate as substrate. Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family. | 0.455 |
ABK72942.1 | ABK71916.1 | MSMEG_5732 | MSMEG_5998 | Monooxygenase; Identified by match to protein family HMM PF00296. | Conserved hypothetical protein; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | 0.590 |