node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71359.1 | ABK71806.1 | MSMEG_4348 | MSMEG_1488 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 0.919 |
ABK71359.1 | ABK72975.1 | MSMEG_4348 | MSMEG_1986 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Tartrate dehydrogenase; Identified by similarity to SP:Q51945; match to protein family HMM PF00180; match to protein family HMM TIGR02089. | 0.953 |
ABK71359.1 | ABK72982.1 | MSMEG_4348 | MSMEG_3285 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 3-isopropylmalate dehydrogenase; Identified by match to protein family HMM PF00180. | 0.947 |
ABK71359.1 | ABK74373.1 | MSMEG_4348 | MSMEG_4460 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.907 |
ABK71359.1 | ilvA | MSMEG_4348 | MSMEG_3183 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.939 |
ABK71359.1 | ilvB | MSMEG_4348 | MSMEG_2372 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.920 |
ABK71359.1 | ilvC | MSMEG_4348 | MSMEG_2374 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.969 |
ABK71359.1 | ilvN | MSMEG_4348 | MSMEG_2373 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119; Belongs to the acetolactate synthase small subunit family. | 0.989 |
ABK71359.1 | leuA | MSMEG_4348 | MSMEG_6271 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.927 |
ABK71359.1 | leuB | MSMEG_4348 | MSMEG_2379 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.956 |
ABK71806.1 | ABK71359.1 | MSMEG_1488 | MSMEG_4348 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 0.919 |
ABK71806.1 | ABK72975.1 | MSMEG_1488 | MSMEG_1986 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Tartrate dehydrogenase; Identified by similarity to SP:Q51945; match to protein family HMM PF00180; match to protein family HMM TIGR02089. | 0.947 |
ABK71806.1 | ABK72982.1 | MSMEG_1488 | MSMEG_3285 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 3-isopropylmalate dehydrogenase; Identified by match to protein family HMM PF00180. | 0.960 |
ABK71806.1 | ABK74373.1 | MSMEG_1488 | MSMEG_4460 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.927 |
ABK71806.1 | ilvA | MSMEG_1488 | MSMEG_3183 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.954 |
ABK71806.1 | ilvB | MSMEG_1488 | MSMEG_2372 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.930 |
ABK71806.1 | ilvC | MSMEG_1488 | MSMEG_2374 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.982 |
ABK71806.1 | ilvN | MSMEG_1488 | MSMEG_2373 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119; Belongs to the acetolactate synthase small subunit family. | 0.992 |
ABK71806.1 | leuA | MSMEG_1488 | MSMEG_6271 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.923 |
ABK71806.1 | leuB | MSMEG_1488 | MSMEG_2379 | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.958 |