node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70452.1 | ABK72131.1 | MSMEG_1196 | MSMEG_4912 | SNF2 domain protein; Identified by match to protein family HMM PF00176. | Putative helicase. | 0.870 |
ABK70452.1 | gmk | MSMEG_1196 | MSMEG_3051 | SNF2 domain protein; Identified by match to protein family HMM PF00176. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.785 |
ABK70452.1 | rpoA | MSMEG_1196 | MSMEG_1524 | SNF2 domain protein; Identified by match to protein family HMM PF00176. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.976 |
ABK70452.1 | rpoB | MSMEG_1196 | MSMEG_1367 | SNF2 domain protein; Identified by match to protein family HMM PF00176. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.975 |
ABK70452.1 | rpoC | MSMEG_1196 | MSMEG_1368 | SNF2 domain protein; Identified by match to protein family HMM PF00176. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.939 |
ABK70452.1 | rpoZ | MSMEG_1196 | MSMEG_3053 | SNF2 domain protein; Identified by match to protein family HMM PF00176. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.977 |
ABK72131.1 | ABK70452.1 | MSMEG_4912 | MSMEG_1196 | Putative helicase. | SNF2 domain protein; Identified by match to protein family HMM PF00176. | 0.870 |
ABK72131.1 | rpoA | MSMEG_4912 | MSMEG_1524 | Putative helicase. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.962 |
ABK72131.1 | rpoB | MSMEG_4912 | MSMEG_1367 | Putative helicase. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.959 |
ABK72131.1 | rpoC | MSMEG_4912 | MSMEG_1368 | Putative helicase. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.840 |
ABK72131.1 | rpoZ | MSMEG_4912 | MSMEG_3053 | Putative helicase. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.967 |
ABK76141.1 | gmk | MSMEG_3050 | MSMEG_3051 | Integration host factor. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.915 |
ABK76141.1 | rpoA | MSMEG_3050 | MSMEG_1524 | Integration host factor. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.940 |
ABK76141.1 | rpoB | MSMEG_3050 | MSMEG_1367 | Integration host factor. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.923 |
ABK76141.1 | rpoC | MSMEG_3050 | MSMEG_1368 | Integration host factor. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.843 |
ABK76141.1 | rpoZ | MSMEG_3050 | MSMEG_3053 | Integration host factor. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.954 |
carD | rbpA | MSMEG_6077 | MSMEG_3858 | Transcriptional regulator, CarD family protein; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for the stringent response to starvation, oxidative and genotoxic stresses as well as control of rRNA under normal growth conditions. | Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB). | 0.994 |
carD | rpoA | MSMEG_6077 | MSMEG_1524 | Transcriptional regulator, CarD family protein; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for the stringent response to starvation, oxidative and genotoxic stresses as well as control of rRNA under normal growth conditions. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.977 |
carD | rpoB | MSMEG_6077 | MSMEG_1367 | Transcriptional regulator, CarD family protein; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for the stringent response to starvation, oxidative and genotoxic stresses as well as control of rRNA under normal growth conditions. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.999 |
carD | rpoC | MSMEG_6077 | MSMEG_1368 | Transcriptional regulator, CarD family protein; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for the stringent response to starvation, oxidative and genotoxic stresses as well as control of rRNA under normal growth conditions. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.988 |