node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71061.1 | hemE | MSMEG_2782 | MSMEG_2780 | Conserved hypothetical protein; Identified by match to protein family HMM PF06778. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.939 |
ABK71061.1 | hemG | MSMEG_2782 | MSMEG_2781 | Conserved hypothetical protein; Identified by match to protein family HMM PF06778. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.952 |
ABK71061.1 | hemH | MSMEG_2782 | MSMEG_3152 | Conserved hypothetical protein; Identified by match to protein family HMM PF06778. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.965 |
ABK72276.1 | ABK73730.1 | MSMEG_2615 | MSMEG_5512 | Chelatase; Identified by match to protein family HMM PF00092; match to protein family HMM PF01078; match to protein family HMM PF07728. | Magnesium chelatase. | 0.971 |
ABK72276.1 | hemE | MSMEG_2615 | MSMEG_2780 | Chelatase; Identified by match to protein family HMM PF00092; match to protein family HMM PF01078; match to protein family HMM PF07728. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.486 |
ABK72276.1 | hemG | MSMEG_2615 | MSMEG_2781 | Chelatase; Identified by match to protein family HMM PF00092; match to protein family HMM PF01078; match to protein family HMM PF07728. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.971 |
ABK72276.1 | hemH | MSMEG_2615 | MSMEG_3152 | Chelatase; Identified by match to protein family HMM PF00092; match to protein family HMM PF01078; match to protein family HMM PF07728. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.946 |
ABK73730.1 | ABK72276.1 | MSMEG_5512 | MSMEG_2615 | Magnesium chelatase. | Chelatase; Identified by match to protein family HMM PF00092; match to protein family HMM PF01078; match to protein family HMM PF07728. | 0.971 |
ABK73730.1 | hemG | MSMEG_5512 | MSMEG_2781 | Magnesium chelatase. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.926 |
ABK73730.1 | hemH | MSMEG_5512 | MSMEG_3152 | Magnesium chelatase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.936 |
bfr | bfrB | MSMEG_3564 | MSMEG_6422 | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | Ferritin family protein; Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. | 0.992 |
bfr | hemH | MSMEG_3564 | MSMEG_3152 | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.925 |
bfrB | bfr | MSMEG_6422 | MSMEG_3564 | Ferritin family protein; Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | 0.992 |
bfrB | hemH | MSMEG_6422 | MSMEG_3152 | Ferritin family protein; Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.927 |
cyoE | hemE | MSMEG_3105 | MSMEG_2780 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.459 |
cyoE | hemH | MSMEG_3105 | MSMEG_3152 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.930 |
fabG-3 | hemH | MSMEG_3150 | MSMEG_3152 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.840 |
fabG-3 | inhA | MSMEG_3150 | MSMEG_3151 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | [NADH] enoyl-[acyl-carrier-protein] reductase; Enoyl-ACP reductase of the type II fatty acid syntase (FAS- II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the double bond of 2-trans- enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway. Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates (By similarity). The mycobacterial FAS-II system utilizes th [...] | 0.988 |
hemE | ABK71061.1 | MSMEG_2780 | MSMEG_2782 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Conserved hypothetical protein; Identified by match to protein family HMM PF06778. | 0.939 |
hemE | ABK72276.1 | MSMEG_2780 | MSMEG_2615 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Chelatase; Identified by match to protein family HMM PF00092; match to protein family HMM PF01078; match to protein family HMM PF07728. | 0.486 |