node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70014.1 | ppm1 | MSMEG_4700 | MSMEG_3859 | ABC-transporter protein, ATP binding component; Identified by match to protein family HMM PF00005. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.742 |
ABK71029.1 | ppm1 | MSMEG_5655 | MSMEG_3859 | Identified by match to protein family HMM PF00795. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.826 |
ABK73064.1 | ABK73409.1 | MSMEG_3861 | MSMEG_3862 | Amidohydrolase 3; Identified by match to protein family HMM PF07969. | FxsA cytoplasmic membrane protein; Identified by match to protein family HMM PF04186. | 0.870 |
ABK73064.1 | lnt | MSMEG_3861 | MSMEG_3860 | Amidohydrolase 3; Identified by match to protein family HMM PF07969. | Polyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown). Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity. | 0.916 |
ABK73064.1 | ppm1 | MSMEG_3861 | MSMEG_3859 | Amidohydrolase 3; Identified by match to protein family HMM PF07969. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.905 |
ABK73409.1 | ABK73064.1 | MSMEG_3862 | MSMEG_3861 | FxsA cytoplasmic membrane protein; Identified by match to protein family HMM PF04186. | Amidohydrolase 3; Identified by match to protein family HMM PF07969. | 0.870 |
ABK73409.1 | lnt | MSMEG_3862 | MSMEG_3860 | FxsA cytoplasmic membrane protein; Identified by match to protein family HMM PF04186. | Polyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown). Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity. | 0.834 |
ABK73409.1 | ppm1 | MSMEG_3862 | MSMEG_3859 | FxsA cytoplasmic membrane protein; Identified by match to protein family HMM PF04186. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.797 |
ABK73691.1 | ppm1 | MSMEG_6926 | MSMEG_3859 | tRNA adenylyltransferase; Identified by match to protein family HMM PF01743; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR02692; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.622 |
glfT2 | mgtA | MSMEG_6403 | MSMEG_1113 | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | Glycosyl transferase; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)- glycerol(ManGlcAGroAc2); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. | 0.762 |
glfT2 | pimB | MSMEG_6403 | MSMEG_4253 | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | Glycosyl transferase, group 1 family protein; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 6 of a phosphatidyl-myo- inositol bearing an alpha-1,2-linked mannose residue (PIM1) to generate phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2). PimB also catalyzes the addition of a mannosyl residue from GDP-Man to the position 6 of phos [...] | 0.740 |
glfT2 | ppm1 | MSMEG_6403 | MSMEG_3859 | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.690 |
lnt | ABK73064.1 | MSMEG_3860 | MSMEG_3861 | Polyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown). Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity. | Amidohydrolase 3; Identified by match to protein family HMM PF07969. | 0.916 |
lnt | ABK73409.1 | MSMEG_3860 | MSMEG_3862 | Polyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown). Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity. | FxsA cytoplasmic membrane protein; Identified by match to protein family HMM PF04186. | 0.834 |
lnt | pimE | MSMEG_3860 | MSMEG_5149 | Polyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown). Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity. | Conserved transmembrane protein; Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol pentamannoside (AcPIM5) to generate a monoacyl phosphatidylinositol hexamannoside (AcPIM6). | 0.414 |
lnt | ppm1 | MSMEG_3860 | MSMEG_3859 | Polyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown). Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.996 |
mgtA | glfT2 | MSMEG_1113 | MSMEG_6403 | Glycosyl transferase; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)- glycerol(ManGlcAGroAc2); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | 0.762 |
mgtA | pimE | MSMEG_1113 | MSMEG_5149 | Glycosyl transferase; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)- glycerol(ManGlcAGroAc2); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. | Conserved transmembrane protein; Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol pentamannoside (AcPIM5) to generate a monoacyl phosphatidylinositol hexamannoside (AcPIM6). | 0.899 |
mgtA | ppm1 | MSMEG_1113 | MSMEG_3859 | Glycosyl transferase; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)- glycerol(ManGlcAGroAc2); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. | Glycosyl transferase, group 2 family protein; Transfers mannose from GDP-mannose to lipid acceptors to form polyprenol monophosphomannose (PPM); catalytic activity in vitro is enhanced by Lnt (AC A0QZ13). PMM is an alkai-stable sugar donor which adds mannose-phosphate residues to triacylated-PIM2, eventually leading to generation of the cell wall glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM) (By similarity). | 0.830 |
pimB | glfT2 | MSMEG_4253 | MSMEG_6403 | Glycosyl transferase, group 1 family protein; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 6 of a phosphatidyl-myo- inositol bearing an alpha-1,2-linked mannose residue (PIM1) to generate phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2). PimB also catalyzes the addition of a mannosyl residue from GDP-Man to the position 6 of phos [...] | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | 0.740 |