STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
ABK72415.1Glycoside hydrolase; Catalyzes the hydrolysis of alpha,alpha-trehalose into two molecules of D-glucose. Does not hydrolyze maltose, isomaltose, sucrose, cellobiose, p-nitrophenyl-alpha-D-glucopyranoside, and methyl- alpha-D-glucopyranoside. Is also inactive on alpha,beta-trehalose, beta,beta-trehalose, alpha,alpha-trehalose-6,6'-dibehenate, trehalulose, nigerose, and trehalose dimycolate. (668 aa)    
Predicted Functional Partners:
otsB
Trehalose-phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
  
 0.998
treS
Trehalose synthase; Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Maltose is the preferred substrate. To a lesser extent, also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D- glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Might also functio [...]
 
 
 0.992
treZ
Malto-oligosyltrehalose trehalohydrolase; Identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02402.
 
 
 0.987
ABK70965.1
Glycosyl transferase; Identified by match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636.
   
 
 0.911
otsA
Alpha,alpha-trehalose-phosphate synthase (UDP-forming); Involved in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1- phosphate (M1P), and probably in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to glucose-6-phosphate (Glc-6-P) to form trehalose-6-phosphate. ADP-Glc, CDP-Glc, GDP- Glc and TDP-Glc are also glucosyl donors, however, when the pyrimidine sugar nucleotides (CDP-Glc, TDP-Glc and UDP-Glc) are used as substrates, there is an absolute requirement [...]
 
  
 0.899
glgE
Alpha-amylase family protein; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is also able to catalyze the reverse reaction in vitro. Cannot use glucose 1-phosphate as substrate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.
 
  
 0.735
ABK72133.1
Trehalose 6-phosphate phosphorylase; Identified by match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636.
  
   
 0.650
ABK69730.1
Putative conserved membrane protein.
  
    0.604
ABK69654.1
Glucokinase; Identified by match to protein family HMM PF00480.
  
 
  0.567
ABK72872.1
Aldose 1-epimerase subfamily protein; Identified by match to protein family HMM PF01263.
  
 
 0.553
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.