node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70694.1 | ABK72053.1 | MSMEG_4240 | MSMEG_1133 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.930 |
ABK70694.1 | dxr | MSMEG_4240 | MSMEG_2578 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.454 |
ABK70694.1 | fni | MSMEG_4240 | MSMEG_1057 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.916 |
ABK70694.1 | ispH | MSMEG_4240 | MSMEG_5224 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.952 |
ABK70694.1 | uppS | MSMEG_4240 | MSMEG_4490 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and heptaprenyl diphosphate are synthesized. It is probably due to the fact that M.smegmatis synthesizes both (2E,6E,10E)- geranylgeranyl diphosphate (EEE-GGPP) and (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP). Can als [...] | 0.809 |
ABK70694.1 | uppS-2 | MSMEG_4240 | MSMEG_5256 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.976 |
ABK71912.1 | uppS-2 | MSMEG_5255 | MSMEG_5256 | Conserved hypothetical protein. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.871 |
ABK72053.1 | ABK70694.1 | MSMEG_1133 | MSMEG_4240 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.930 |
ABK72053.1 | cysS-2 | MSMEG_1133 | MSMEG_6074 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | cysteinyl-tRNA synthetase; Identified by match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.414 |
ABK72053.1 | fni | MSMEG_1133 | MSMEG_1057 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.583 |
ABK72053.1 | uppS | MSMEG_1133 | MSMEG_4490 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and heptaprenyl diphosphate are synthesized. It is probably due to the fact that M.smegmatis synthesizes both (2E,6E,10E)- geranylgeranyl diphosphate (EEE-GGPP) and (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP). Can als [...] | 0.805 |
ABK72053.1 | uppS-2 | MSMEG_1133 | MSMEG_5256 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.884 |
cdsA | dxr | MSMEG_2543 | MSMEG_2578 | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.785 |
cdsA | frr | MSMEG_2543 | MSMEG_2541 | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.929 |
cdsA | uppS | MSMEG_2543 | MSMEG_4490 | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and heptaprenyl diphosphate are synthesized. It is probably due to the fact that M.smegmatis synthesizes both (2E,6E,10E)- geranylgeranyl diphosphate (EEE-GGPP) and (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP). Can als [...] | 0.809 |
cdsA | uppS-2 | MSMEG_2543 | MSMEG_5256 | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.764 |
cysS-2 | ABK72053.1 | MSMEG_6074 | MSMEG_1133 | cysteinyl-tRNA synthetase; Identified by match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.414 |
cysS-2 | uppS | MSMEG_6074 | MSMEG_4490 | cysteinyl-tRNA synthetase; Identified by match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and heptaprenyl diphosphate are synthesized. It is probably due to the fact that M.smegmatis synthesizes both (2E,6E,10E)- geranylgeranyl diphosphate (EEE-GGPP) and (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP). Can als [...] | 0.543 |
cysS-2 | uppS-2 | MSMEG_6074 | MSMEG_5256 | cysteinyl-tRNA synthetase; Identified by match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.729 |
dxr | ABK70694.1 | MSMEG_2578 | MSMEG_4240 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.454 |