node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
lfrA | mspA | MSMEG_6225 | MSMEG_0965 | Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | 0.517 |
lfrA | mspC | MSMEG_6225 | MSMEG_5483 | Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.440 |
mspA | lfrA | MSMEG_0965 | MSMEG_6225 | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. | 0.517 |
mspA | mspB | MSMEG_0965 | MSMEG_0520 | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | Porin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.551 |
mspA | mspC | MSMEG_0965 | MSMEG_5483 | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.552 |
mspA | mspD | MSMEG_0965 | MSMEG_6057 | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. | 0.551 |
mspB | mspA | MSMEG_0520 | MSMEG_0965 | Porin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | 0.551 |
mspB | mspC | MSMEG_0520 | MSMEG_5483 | Porin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.554 |
mspB | mspD | MSMEG_0520 | MSMEG_6057 | Porin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. | MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. | 0.553 |
mspC | lfrA | MSMEG_5483 | MSMEG_6225 | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. | 0.440 |
mspC | mspA | MSMEG_5483 | MSMEG_0965 | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | 0.552 |
mspC | mspB | MSMEG_5483 | MSMEG_0520 | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | Porin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.554 |
mspC | mspD | MSMEG_5483 | MSMEG_6057 | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. | 0.552 |
mspD | mspA | MSMEG_6057 | MSMEG_0965 | MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. | Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...] | 0.551 |
mspD | mspB | MSMEG_6057 | MSMEG_0520 | MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. | Porin; A backup porin induced when MspA, the major porin, is deleted. Probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. A triple mspA- mspC-mspD deletion mutant has low but detectable channel activity. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspB channels into the membrane or by the existence of different MspB conformations. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.553 |
mspD | mspC | MSMEG_6057 | MSMEG_5483 | MspD protein; A backup porin induced when MspA, the major porin, is deleted. It probably forms a water-filled channel which favors the permeation of cations. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. | Porin; A constitutively expressed secondary porin, forms a water- filled channel which favors the permeation of cations and less efficiently phosphate. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Belongs to the mycobacterial porin (TC 1.B.24) family. | 0.552 |