STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mprBSensor histidine kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). (506 aa)    
Predicted Functional Partners:
mprA
DNA-binding response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).
 
 0.999
prrA
DNA-binding response regulator PrrA; Identified by similarity to SP:Q10531; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.885
ABK72873.1
Two component response transcriptional regulatory protein prra; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.867
regX3
DNA-binding response regulator RegX3; Part of the two-component regulatory system SenX3/RegX3. Once phosphorylated by SenX3, activates the expression of several operons/genes involved in phosphate assimilation and metabolism, such as pstSCAB, phnDCE, and phoA.
 
 
 0.853
ABK73706.1
DNA-binding response regulator, PhoP family protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.840
ABK72654.1
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.832
resD
DNA-binding response regulator ResD; Identified by similarity to SP:P35163; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.828
mtrA
DNA-binding response regulator MtrA; Member of the two-component regulatory system MtrA/MtrB, responding to environmental signals (Probable). Controls expression of a number of genes including dnaA, ripA, fbpB and probably itself. Probably plays a role in cell division.
 
 
 0.811
phoP
DNA-binding response regulator PhoP; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.792
ABK74820.1
KDP operon transcriptional regulatory protein KdpE; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.760
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.