node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70121.1 | dnl1 | MSMEG_2105 | MSMEG_2277 | ATP dependent DNA ligase. | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | 0.507 |
ABK70121.1 | ku | MSMEG_2105 | MSMEG_5580 | ATP dependent DNA ligase. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.871 |
ABK70121.1 | ligC | MSMEG_2105 | MSMEG_6302 | ATP dependent DNA ligase. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. Belongs to the ATP-dependent DNA ligase family. | 0.877 |
ABK70121.1 | ligC2 | MSMEG_2105 | MSMEG_6304 | ATP dependent DNA ligase. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.782 |
ABK71856.1 | ku | MSMEG_1952 | MSMEG_5580 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00570; match to protein family HMM PF00580. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.644 |
ABK71856.1 | ligD-2 | MSMEG_1952 | MSMEG_5570 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00570; match to protein family HMM PF00580. | DNA ligase; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang DNA double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ during 3'-overhang repair. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. Acts as a DNA ligase on singly nicked dsDNA, as a DNA-directed DNA polymerase on 5' overhangs, and adds non-templated nucleotides to 3' overhangs (terminal transferase). Fills in gaps in d [...] | 0.403 |
ABK71856.1 | pcrA | MSMEG_1952 | MSMEG_5534 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00570; match to protein family HMM PF00580. | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. | 0.966 |
ABK72575.1 | dnl1 | MSMEG_0597 | MSMEG_2277 | Conserved hypothetical protein. | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | 0.918 |
ABK72575.1 | ku | MSMEG_0597 | MSMEG_5580 | Conserved hypothetical protein. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.924 |
ABK72575.1 | ligC | MSMEG_0597 | MSMEG_6302 | Conserved hypothetical protein. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. Belongs to the ATP-dependent DNA ligase family. | 0.946 |
ABK72575.1 | ligC2 | MSMEG_0597 | MSMEG_6304 | Conserved hypothetical protein. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.954 |
ABK72752.1 | ku | MSMEG_6715 | MSMEG_5580 | Identified by match to protein family HMM PF01261. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.593 |
ABK72752.1 | ligD-2 | MSMEG_6715 | MSMEG_5570 | Identified by match to protein family HMM PF01261. | DNA ligase; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang DNA double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ during 3'-overhang repair. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. Acts as a DNA ligase on singly nicked dsDNA, as a DNA-directed DNA polymerase on 5' overhangs, and adds non-templated nucleotides to 3' overhangs (terminal transferase). Fills in gaps in d [...] | 0.455 |
dnl1 | ABK70121.1 | MSMEG_2277 | MSMEG_2105 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | ATP dependent DNA ligase. | 0.507 |
dnl1 | ABK72575.1 | MSMEG_2277 | MSMEG_0597 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | Conserved hypothetical protein. | 0.918 |
dnl1 | ku | MSMEG_2277 | MSMEG_5580 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.884 |
dnl1 | ligC | MSMEG_2277 | MSMEG_6302 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. Belongs to the ATP-dependent DNA ligase family. | 0.673 |
dnl1 | ligC2 | MSMEG_2277 | MSMEG_6304 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.679 |
dnl1 | ligD | MSMEG_2277 | MSMEG_6301 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | DNA polymerase LigD, polymerase domain; Identified by match to protein family HMM TIGR02778. | 0.838 |
dnl1 | ligD-2 | MSMEG_2277 | MSMEG_5570 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. | DNA ligase; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang DNA double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ during 3'-overhang repair. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. Acts as a DNA ligase on singly nicked dsDNA, as a DNA-directed DNA polymerase on 5' overhangs, and adds non-templated nucleotides to 3' overhangs (terminal transferase). Fills in gaps in d [...] | 0.951 |