node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70591.1 | ABK70837.1 | MSMEG_2870 | MSMEG_4864 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | 0.968 |
ABK70591.1 | ABK70902.1 | MSMEG_2870 | MSMEG_2869 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | 3-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. | 0.991 |
ABK70591.1 | ABK72155.1 | MSMEG_2870 | MSMEG_2893 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | Oxidoreductase, NAD/FAD-binding; Identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970. | 0.966 |
ABK70591.1 | ABK72635.1 | MSMEG_2870 | MSMEG_2867 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | 0.957 |
ABK70591.1 | ABK73895.1 | MSMEG_2870 | MSMEG_6036 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | Biphenyl-2,3-diol 1,2-dioxygenase; Identified by match to protein family HMM PF00903. | 0.867 |
ABK70591.1 | ksdD | MSMEG_2870 | MSMEG_5941 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | 3-ketosteroid dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to. | 0.988 |
ABK70591.1 | kshA | MSMEG_2870 | MSMEG_5925 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | Rieske [2Fe-2S] domain protein; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. | 0.903 |
ABK70591.1 | kshB | MSMEG_2870 | MSMEG_6039 | Oxygenase KshA; Identified by match to protein family HMM PF00355. | Oxidoreductase, electron transfer component; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. | 0.995 |
ABK70837.1 | ABK70591.1 | MSMEG_4864 | MSMEG_2870 | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | Oxygenase KshA; Identified by match to protein family HMM PF00355. | 0.968 |
ABK70837.1 | ABK72155.1 | MSMEG_4864 | MSMEG_2893 | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | Oxidoreductase, NAD/FAD-binding; Identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970. | 0.929 |
ABK70837.1 | ABK73895.1 | MSMEG_4864 | MSMEG_6036 | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | Biphenyl-2,3-diol 1,2-dioxygenase; Identified by match to protein family HMM PF00903. | 0.821 |
ABK70837.1 | kshA | MSMEG_4864 | MSMEG_5925 | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | Rieske [2Fe-2S] domain protein; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. | 0.964 |
ABK70837.1 | kshB | MSMEG_4864 | MSMEG_6039 | 3-ketosteroid dehydrogenase; Identified by match to protein family HMM PF00890. | Oxidoreductase, electron transfer component; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. | 0.929 |
ABK70902.1 | ABK70591.1 | MSMEG_2869 | MSMEG_2870 | 3-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. | Oxygenase KshA; Identified by match to protein family HMM PF00355. | 0.991 |
ABK70902.1 | ABK72155.1 | MSMEG_2869 | MSMEG_2893 | 3-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. | Oxidoreductase, NAD/FAD-binding; Identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970. | 0.928 |
ABK70902.1 | ABK73895.1 | MSMEG_2869 | MSMEG_6036 | 3-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. | Biphenyl-2,3-diol 1,2-dioxygenase; Identified by match to protein family HMM PF00903. | 0.818 |
ABK70902.1 | kshA | MSMEG_2869 | MSMEG_5925 | 3-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. | Rieske [2Fe-2S] domain protein; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. | 0.964 |
ABK70902.1 | kshB | MSMEG_2869 | MSMEG_6039 | 3-ketosteroid-delta-1-dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266. | Oxidoreductase, electron transfer component; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. | 0.927 |
ABK71069.1 | cyp142 | MSMEG_1499 | MSMEG_5918 | Oxygenase; Identified by match to protein family HMM PF01266; match to protein family HMM PF01494. | P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. | 0.607 |
ABK71069.1 | ksdD | MSMEG_1499 | MSMEG_5941 | Oxygenase; Identified by match to protein family HMM PF01266; match to protein family HMM PF01494. | 3-ketosteroid dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to. | 0.770 |