STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lfrAProton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. (504 aa)    
Predicted Functional Partners:
lfrR
TetR family protein transcriptional repressor LfrR; Represses the transcription of the lfrRA operon by binding directly to the promoter region of lfrR-lfrA. Binds specifically to a 143-bp region upstream of the lfrR gene.
  
  
 0.934
ABK76108.1
Membrane transport protein; Identified by match to protein family HMM PF07690.
 
   
 0.717
ABK74144.1
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
   
 
 0.666
ABK72530.1
Possible drug efflux membrane protein; Identified by match to protein family HMM PF07690.
 
  
 0.650
ABK71516.1
Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.
  
  
 0.638
ABK75742.1
Identified by match to protein family HMM PF07690.
  
  
 0.599
ABK71801.1
ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005.
   
 
 0.599
ABK72667.1
Major facilitator superfamily protein MFS_1; Probably plays a role in bacterial growth and resistance to antibiotics.
     
 0.595
ABK70221.1
Transcriptional regulator; Identified by match to protein family HMM PF00440.
     
 0.520
mspA
Porin; The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA [...]
   
  
 0.517
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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