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ligC2 protein (Mycobacterium smegmatis MC2155) - STRING interaction network
"ligC2" - DNA ligase C2 in Mycobacterium smegmatis MC2155
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Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ligC2DNA ligase C2; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku- LigD-dependent NHEJ pathway (354 aa)    
Predicted Functional Partners:
MSMEG_6301
annotation not available (349 aa)
   
  0.991
MSMEG_0597
annotation not available (412 aa)
     
  0.906
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (908 aa)
   
 
  0.889
MSMEG_2105
annotation not available (321 aa)
     
  0.863
MSMEG_6343
annotation not available (165 aa)
     
   
  0.852
ku
Non-homologous end joining protein Ku; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5’-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non- complementary 3’ ends. Plays a partial role in NHEJ on 3’-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5’ overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect [...] (318 aa)
 
   
  0.825
ligA
DNA ligase A; DNA ligase that catalyzes the formation of phosphodiester linkages between 5’-phosphoryl and 3’-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (Probable). Probably the only ligase required for non-homologous end joining (NHEJ) repair of 3-overhangs; Belongs to the NAD-dependent DNA ligase family. LigA subfamily (701 aa)
           
  0.750
recA
Protein RecA; Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the e [...] (349 aa)
   
 
  0.747
MSMEG_5545
annotation not available (288 aa)
   
   
  0.743
dnaN
Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...] (397 aa)
   
 
  0.710
Your Current Organism:
Mycobacterium smegmatis MC2155
NCBI taxonomy Id: 246196
Other names: M. smegmatis str. MC2 155, Mycobacterium smegmatis MC2 155, Mycobacterium smegmatis MC2155, Mycobacterium smegmatis str. MC2 155, Mycobacterium smegmatis strain MC2 155
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