STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfnBNfnB protein; Confers resistance to antitubercular drugs benzothiazinone (BTZ) and dinitrobenzamide (DNB). Inactivates BTZ and DNB by reducing an essential nitro group of these compounds to amino group or to hydroxyl amine, respectively, using NADH or NADPH as source of reducing equivalents; two electrons are transferred. Able to reduce the nitro group of bicyclic nitroimidazole PA-824, but not of quinone menadione, nitrofurazone, methyl-4-nitrobenzoate, 4-nitrobenzene methyl sulfonate or 4- nitroacetophenone. (234 aa)    
Predicted Functional Partners:
ABK73461.1
Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440.
  
  
 0.915
dprE1
Oxidoreductase, FAD-binding; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate chann [...]
  
  
 0.767
ABK76102.1
Nicotinamidase/pyrazinamidase; Identified by match to protein family HMM PF00857.
  
  
 0.761
dprE2
Putative oxidoreductase in MprA 5'region; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'su [...]
  
  
 0.760
ABK71153.1
ABC-type drug export system, membrane protein; Identified by match to protein family HMM PF01061.
  
  
 0.552
ABK73980.1
Cadmium inducible protein cadi; Identified by match to protein family HMM PF00903.
 
  
 0.492
ABK72259.1
acyl-CoA synthase; Identified by match to protein family HMM PF00501.
  
 
 0.481
ABK73913.1
Peroxisomal-coenzyme A synthetase; Identified by match to protein family HMM PF00501.
  
 
 0.481
ABK72382.1
acyl-CoA synthase; Identified by match to protein family HMM PF00501.
  
 
 0.480
ABK73186.1
AMP-binding enzyme; Identified by match to protein family HMM PF00501.
  
 
 0.480
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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