STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ino1Myo-inositol-1-phosphate synthase; Catalyzes the conversion of glucose 6-phosphate to 1D-myo- inositol 3-phosphate; Belongs to the myo-inositol 1-phosphate synthase family. (363 aa)    
Predicted Functional Partners:
impA
Inositol monophosphate phosphatase; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria.
  
 
 0.988
ABK72681.1
Inositol-1-monophosphatase; Identified by match to protein family HMM PF00459.
  
 
 0.972
ABK69903.1
Inositol-1-monophosphatase; Identified by match to protein family HMM PF00459; Belongs to the inositol monophosphatase superfamily.
  
 
 0.972
pgm
Phosphoglucomutase, alpha-D-glucose phosphate-specific; Identified by similarity to SP:P36938; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; match to protein family HMM TIGR01132.
   
 
 0.926
ABK69654.1
Glucokinase; Identified by match to protein family HMM PF00480.
   
 
 0.907
ABK75692.1
Identified by match to protein family HMM PF00480.
   
 
 0.905
ABK73510.1
Transcriptional regulator, PadR family protein; Identified by match to protein family HMM PF03551.
 
  
 0.894
pgsA-2
Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
  
 0.853
mshA
Conserved hypothetical protein; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway; Belongs to the glycosyltransferase group 1 family. MshA subfamily.
 
 
 0.827
ABK71430.1
Putative hydrolase; Identified by match to protein family HMM PF00561.
  
   0.789
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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