node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MXAN_4593 | fhs | MXAN_4593 | MXAN_0175 | Hypothetical protein; Identified by Glimmer2; putative. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.961 |
MXAN_4593 | folA | MXAN_4593 | MXAN_5943 | Hypothetical protein; Identified by Glimmer2; putative. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.919 |
MXAN_4593 | folD | MXAN_4593 | MXAN_2226 | Hypothetical protein; Identified by Glimmer2; putative. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.963 |
MXAN_4593 | folD-2 | MXAN_4593 | MXAN_3032 | Hypothetical protein; Identified by Glimmer2; putative. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.963 |
MXAN_4593 | gcvT | MXAN_4593 | MXAN_3040 | Hypothetical protein; Identified by Glimmer2; putative. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.985 |
MXAN_4593 | glyA | MXAN_4593 | MXAN_4766 | Hypothetical protein; Identified by Glimmer2; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
MXAN_4593 | metH | MXAN_4593 | MXAN_1971 | Hypothetical protein; Identified by Glimmer2; putative. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.932 |
MXAN_4593 | purH | MXAN_4593 | MXAN_2914 | Hypothetical protein; Identified by Glimmer2; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.976 |
MXAN_4593 | purL | MXAN_4593 | MXAN_2349 | Hypothetical protein; Identified by Glimmer2; putative. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.913 |
MXAN_4593 | purN | MXAN_4593 | MXAN_2700 | Hypothetical protein; Identified by Glimmer2; putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.965 |
fhs | MXAN_4593 | MXAN_0175 | MXAN_4593 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Hypothetical protein; Identified by Glimmer2; putative. | 0.961 |
fhs | folA | MXAN_0175 | MXAN_5943 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.958 |
fhs | folD | MXAN_0175 | MXAN_2226 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.993 |
fhs | folD-2 | MXAN_0175 | MXAN_3032 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.993 |
fhs | gcvT | MXAN_0175 | MXAN_3040 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.941 |
fhs | glyA | MXAN_0175 | MXAN_4766 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
fhs | metH | MXAN_0175 | MXAN_1971 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.946 |
fhs | purH | MXAN_0175 | MXAN_2914 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.981 |
fhs | purL | MXAN_0175 | MXAN_2349 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.935 |
fhs | purN | MXAN_0175 | MXAN_2700 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.971 |