STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.986
sdhA
Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P08065; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01811.
 
 0.978
frdA
Fumarate reductase, flavoprotein subunit; Identified by similarity to GB:AAO42600.1; match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF07992; match to protein family HMM TIGR01811.
 
 0.973
fumB
Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.968
sdhC
Succinate dehydrogenase cytochrome b558 subunit; Identified by similarity to SP:P08064.
  
 
 0.966
sdhB
Succinate dehydrogenase, iron-sulfur protein; Identified by similarity to SP:P08066; match to protein family HMM PF00037; match to protein family HMM TIGR00384.
  
 0.965
frdB
Fumarate reductase, iron-sulfur protein; Identified by match to protein family HMM PF00037.
  
 0.965
aceB
Malate synthase A; Identified by match to protein family HMM PF01274; match to protein family HMM TIGR01344.
    
 0.951
acnA
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.943
citZ
Citrate synthase; Identified by similarity to SP:P39120.
  
 0.919
Your Current Organism:
Myxococcus xanthus
NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622
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