| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO0382 | hemC | SPO0382 | SPO3649 | nifU domain protein; Identified by match to protein family HMM PF01106. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.878 |
| SPO0382 | hemF | SPO0382 | SPO3653 | nifU domain protein; Identified by match to protein family HMM PF01106. | Coproporphyrinogen III oxidase, aerobic; Identified by match to protein family HMM PF01218. | 0.467 |
| SPO0794 | SPO3853 | SPO0794 | SPO3853 | Copper-translocating P-type ATPase; Identified by similarity to SP:P37279; match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525. | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.449 |
| SPO0794 | hemB | SPO0794 | SPO2076 | Copper-translocating P-type ATPase; Identified by similarity to SP:P37279; match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525. | Porphobilinogen synthase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family. | 0.457 |
| SPO0794 | hemC | SPO0794 | SPO3649 | Copper-translocating P-type ATPase; Identified by similarity to SP:P37279; match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.671 |
| SPO3853 | SPO0794 | SPO3853 | SPO0794 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Copper-translocating P-type ATPase; Identified by similarity to SP:P37279; match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525. | 0.449 |
| SPO3853 | cobA-1 | SPO3853 | SPO2632 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.923 |
| SPO3853 | cobA-2 | SPO3853 | SPO2873 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.923 |
| SPO3853 | hemB | SPO3853 | SPO2076 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family. | 0.904 |
| SPO3853 | hemC | SPO3853 | SPO3649 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
| SPO3853 | hemE | SPO3853 | SPO3648 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.947 |
| SPO3853 | hemF | SPO3853 | SPO3653 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Coproporphyrinogen III oxidase, aerobic; Identified by match to protein family HMM PF01218. | 0.457 |
| SPO3853 | hemH | SPO3853 | SPO0073 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.527 |
| SPO3853 | hemL | SPO3853 | SPO1597 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.512 |
| cobA-1 | SPO3853 | SPO2632 | SPO3853 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.923 |
| cobA-1 | cobA-2 | SPO2632 | SPO2873 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.909 |
| cobA-1 | hemB | SPO2632 | SPO2076 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family. | 0.862 |
| cobA-1 | hemC | SPO2632 | SPO3649 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.988 |
| cobA-1 | hemE | SPO2632 | SPO3648 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.918 |
| cobA-1 | hemL | SPO2632 | SPO1597 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Glutamate-1-semialdehyde 2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.475 |
