Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
50S ribosomal protein L34 (44 aa)
Predicted Functional Partners:
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5’-leader sequence from pre-tRNA to produce the mature 5’-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5’-leader sequence and broadening the substrate specificity of the ribozyme (108 aa)
Hypothetical protein (139 aa)
50S ribosomal protein L36 (37 aa)
Glyceraldehyde-3-phosphate dehydrogenase (343 aa)
Glyceraldehyde-3-phosphate dehydrogenase (338 aa)
Thioredoxin (110 aa)
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (203 aa)