Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Pilin biogenesis protein (410 aa)
Predicted Functional Partners:
Twitching motility protein (385 aa)
Pilus biogenesis protein homologous (642 aa)
Type 4 prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (269 aa)
General secretion pathway protein E (525 aa)
Hypothetical protein (621 aa)
Hypothetical protein (632 aa)
Hypothetical protein (343 aa)
Hypothetical protein (493 aa)
Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- depe [...] (196 aa)