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leuS protein (Ehrlichia ruminantium) - STRING interaction network
"leuS" - Leucine--tRNA ligase in Ehrlichia ruminantium
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
leuSLeucine--tRNA ligase; leuS | leucyl-tRNA synthetase | len- 830 aa | Highly similar to many e.g. SYL_ECOLI P07813 Leucyl-tRNA synthetase (860 aa) from Escherichia coli, fasta scores- E()- 4.8e-105, 40.650% identity in 861 aa overlap | Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V) | Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature | Similar to Erum4870, Erum7710, Erum0780 (830 aa)    
Predicted Functional Partners:
mnmE
tRNA modification GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family (439 aa)
   
  0.931
ileS
Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile); Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily (1104 aa)
   
 
0.928
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (359 aa)
 
 
  0.923
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (810 aa)
   
 
0.894
pheT
Phenylalanine--tRNA ligase beta subunit; pheT | phenylalanyl-tRNA synthetase beta chain | len- 789 aa | Highly similar to many e.g. SYFB_ECOLI P07395 Phenylalanyl-tRNA synthetase beta chain (795 aa) from Escherichia coli, fasta scores- E()- 1.7e-76, 31.728% identity in 810 aa overlap | Contains Pfam match to entry PF01588 tRNA_bind, Putative tRNA binding domain, PF03483 B3_4, B3/4 domain, PF03484 B5, tRNA synthetase B5 domain and PF03147 FDX-ACB, Ferredoxin-fold anticodon binding domain (789 aa)
   
   
  0.892
rpmA
rpmA | 50S ribosomal protein L27 | len- 88 aa | Similar to many e.g. RL27_ECOLI P02427 50S ribosomal protein L27 (84 aa) from Escherichia coli, fasta scores- E()- 9.1e-16, 58.025% identity in 81 aa overlap | Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein | Contains PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family (88 aa)
   
 
  0.892
rplQ
rplQ | 50S ribosomal protein L17 | len- 128 aa | Similar to many e.g. RL17_ECOLI P02416 50S ribosomal protein L17 (127 aa) from Escherichia coli, fasta scores- E()- 6.3e-18, 50.820% identity in 122 aa overlap | Contains Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17 | Contains PS01167 Ribosomal protein L17 signature (128 aa)
   
   
  0.890
cysS
Cysteine--tRNA ligase; cysS | cysteinyl-tRNA synthetase | len- 457 aa | Highly similar to many e.g. SYC_ECOLI P21888 Cysteinyl-tRNA synthetase (461 aa) from Escherichia coli, fasta scores- E()- 5.3e-73, 43.966% identity in 464 aa overlap | Contains Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C); Belongs to the class-I aminoacyl-tRNA synthetase family (457 aa)
   
 
  0.886
tilS
tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine; Belongs to the tRNA(Ile)-lysidine synthase family (442 aa)
   
   
  0.871
argS
Arginine--tRNA ligase; argS | arginyl-tRNA synthetase | len- 576 aa | Similar to many e.g. SYR_CORGL P35868 Arginyl-tRNA synthetase (550 aa) from Corynebacterium glutamicum, fasta scores- E()- 2.4e-26, 33.919% identity in 569 aa overlap | Contains Pfam match to entry PF05746 tRNA-synt_1d_C, Arginyl tRNA synthetase anticodon binding domain, PF00750 tRNA-synt_1d, tRNA synthetases class I (R) and PF03485 N-Arg, Arginyl tRNA synthetase N terminal domain | Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature (576 aa)
   
 
  0.850
Your Current Organism:
Ehrlichia ruminantium
NCBI taxonomy Id: 254945
Other names: E. ruminantium str. Welgevonden, Ehrlichia ruminantium, Ehrlichia ruminantium isolate Welgevonden, Ehrlichia ruminantium str. Welgevonden, Ehrlichia ruminantium strain Welgevonden
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