STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa)    
Predicted Functional Partners:
fhs
Formyltetrahydrofolate synthetase; Similar to Staphylococcus aureus (strain N315) formyltetrahydrofolate synthetase Fhs or SA1553 or SAV1732 SWALL:Q99TD2 (EMBL:AP003134) (555 aa) fasta scores: E(): 1.2e-125, 59.34% id in 551 aa, and to Moorella thermoacetica formate--tetrahydrofolate ligase Fhs SWALL:FTHS_MOOTH (SWALL:P21164) (559 aa) fasta scores: E(): 4.9e-116, 55.57% id in 556 aa.
 
 0.995
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.988
purN
5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.964
purH
Similar to Mycobacterium tuberculosis bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydorlase (EC 3.5.4.10)] or Rv0957 or MT0984 or MTCY10D7.17c SW:PUR9_MYCTU (P71553) (523 aa) fasta scores: E(): 1e-137, 68.06% id in 526 aa, and to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydrolase (EC 3.5.4.10)] PurH or B4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1e-58, 45.25% id in 537 aa.
  
 
 0.959
DIP1611
Similar to Streptomyces lividans 5,10-methylenetetrahydrofolate reductase MetF SW:METF_STRLI (O54235) (307 aa) fasta scores: E(): 4.1e-41, 41.58% id in 303 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF or B3941 SW:METF_ECOLI (P00394) (296 aa) fasta scores: E(): 9.2e-15, 33.65% id in 309 aa.
    
 0.944
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.936
DIP2130
Full length similarity to Streptococcus pneumoniae phosphoribosylformylglycinamidine synthase, putative SP0045 TR:AAK74234 (EMBL:AE007322) (1241 aa) fasta scores: E(): 7.8e-167, 47.73% id in 1259 aa. Second two thirds similar to many others e.g. Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PurL or Rv0803 or MT0823 or MTCY07H7A.06c SW:PURL_MYCTU (P54876) (754 aa) fasta scores: E(): 8.3e-22, 26.35% id in 740 aa.
  
  
 0.919
thyX
Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
 
  
 0.917
DIP0861
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 21.3 kDa protein ML0181 or MLCB373.33c TR:Q9Z5G2 (EMBL:AL035500) (197 aa) fasta scores: E(): 2.1e-14, 34.73% id in 190 aa; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
    
 0.915
lpd
Similar to Corynebacterium glutamicum dihydrolipoamide dehydrogenase Lpd TR:Q9Z466 (EMBL:Y16642) (469 aa) fasta scores: E(): 1.1e-135, 78.03% id in 469 aa, and to Zymomonas mobilis dihydrolipoamide dehydrogenase Lpd SW:DLDH_ZYMMO (P50970) (466 aa) fasta scores: E(): 5.7e-66, 43.55% id in 473 aa.
    
 0.907
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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