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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1214Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 15.1 kDa protein Rv1847 or MT1895 or MTCY359.26c SWALL:YI47_MYCTU (SWALL:P95162) (140 aa) fasta scores: E(): 1.6e-08, 34.67% id in 124 aa, and to Pseudomonas aeruginosa hypothetical protein PA1618 SWALL:YG18_PSEAE (SWALL:Q9I3A4) (145 aa) fasta scores: E(): 2e-05, 32.82% id in 131 aa. (152 aa)    
Predicted Functional Partners:
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
 
  
 0.944
gnd
6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
       0.695
DIP1212
Putative RNA helicase; Similar to Streptomyces coelicolor SC10A5.25c protein SWALL:O54116 (EMBL:AL021529) (498 aa) fasta scores: E(): 6.5e-63, 46.93% id in 424 aa, and to Escherichia coli putative ATP-dependent RNA helicase RhlE or B0797 SWALL:RHLE_ECOLI (SWALL:P25888) (454 aa) fasta scores: E(): 7.6e-44, 36.06% id in 452 aa.
       0.592
DIP1209
Conserved hypothetical protein; Similar to Rhodococcus fascians hypothetical 34.0 kDa protein SWALL:Q9AE56 (EMBL:AJ301559) (304 aa) fasta scores: E(): 2.2e-46, 44.91% id in 285 aa.
       0.573
DIP1210
Putative membrane protein; Similar to Rhodococcus fascians hypothetical 40.3 kDa protein SWALL:Q9AE57 (EMBL:AJ301559) (380 aa) fasta scores: E(): 5.4e-62, 50.28% id in 348 aa, to Streptomyces coelicolor putative integral membrane protein SC6D7.04 SWALL:Q9RKZ3 (EMBL:AL133213) (347 aa) fasta scores: E(): 8.2e-47, 40.93% id in 342 aa, and to Bacillus subtilis hypothetical 49.9 kDa protein in citA-sspB intergenic region YhdP SWALL:YHDP_BACSU (SWALL:O07585) (444 aa) fasta scores: E(): 5.3e-34, 34.48% id in 348 aa.
       0.573
DIP1211
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 48.1 kDa protein Rv1842c or MT1890 or MTCY1A11.02 or MTCY359.31 SWALL:YI42_MYCTU (SWALL:Q50592) (455 aa) fasta scores: E(): 8.3e-77, 49.55% id in 444 aa, and to Myxococcus xanthus hemolysin TlyC SWALL:AAK64446 (EMBL:AF377339) (463 aa) fasta scores: E(): 9.4e-38, 34.74% id in 449 aa.
       0.573
DIP1208
Putative secreted protein; No significant database matches.
       0.551
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
  
 
 0.477
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
    0.422
DIP2161
Nonribosomal peptide synthase; Similar to Stigmatella aurantiaca myxothiazol synthase MtaC TR:Q9RFK9 (EMBL:AF188287) (1290 aa) fasta scores: E(): 1.7e-86, 35.694% id in 1073 aa, and to Polyangium cellulosum epothilone biosynthase EpoB TR:Q9KIZ9 (EMBL:AF217189) (1410 aa) fasta scores: E(): 1.8e-81, 35.385% id in 975 aa, and to Pseudomonas aeruginosa pyochelin synthetase PchF or PA4225 TR:Q9HWG4 (EMBL:AE004839) (1809 aa) fasta scores: E(): 1.9e-81, 37.017% id in 932 aa.
  
 
 0.415
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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