STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dtxRDiphtheria toxin repressor; Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess. (226 aa)    
Predicted Functional Partners:
hmuO
Heme oxygenase; Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.
      
 0.914
ripA
Putative araC-family transcriptional regulator; Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.
   
  
 0.882
galE
UDP-glucose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
     
 0.875
hemL
Similar to Streptomyces coelicolor glutamate-1-semialdehyde 2,1-aminomutase HemL or SCD65.12 SW:GSA_STRCO (Q9F2S0) (438 aa) fasta scores: E(): 4e-96, 62.97% id in 424 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC or B0154 SW:GSA_ECOLI (P23893) (426 aa) fasta scores: E(): 1.7e-75, 52.39% id in 418 aa.
      
 0.869
hemA
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
   
  
 0.861
sigB
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.797
ctaE
Similar to Corynebacterium glutamicum cytochrome AA3 oxidase subunit III CtaE TR:Q9AEL8 (EMBL:AJ306418) (205 aa) fasta scores: E(): 9.9e-67, 81.95% id in 205 aa, and to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III CtaE or Rv2193 or MT2249 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 3.6e-47, 60% id in 205 aa.
      
 0.796
DIP1710
Similar to Mycobacterium tuberculosis CDC1551 ferric uptake regulation protein MT2428 TR:AAK46722 (EMBL:AE007082) (130 aa) fasta scores: E(): 6.1e-24, 53.6% id in 125 aa, and to Escherichia coli ferric uptake regulation protein Fur or B0683 or Z0831 or ECS0714 SW:FUR_ECOLI (P06975) (148 aa) fasta scores: E(): 2.4e-10, 29.77% id in 131 aa; Belongs to the Fur family.
  
  
 0.741
chrS
Two-component system histidine kinase ChrS; Previously sequenced and described as Corynebacterium diphtheriae histidine kinase ChrS SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 4e-136, 88.72% id in 417 aa. Similar to many eg. Streptomyces reticuli histidine autokinase SenS SWALL:Q9RIM1 (EMBL:Y14336) (398 aa) fasta scores: E(): 1.6e-21, 35.28% id in 411 aa.
      
 0.730
ctaD
Cytochrome C oxidase polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
      
 0.688
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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