STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (333 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
BP1297
Similar to Pyrococcus abyssi lipoate-protein ligase A related Pab1916 TR:Q9V0V8 (EMBL:AJ248285) (249 aa) fasta scores: E(): 2e-24, 37.02% id in 235 aa, and to Pyrococcus horikoshii 249aa long hypothetical lipoate protein ligase Ph1487 TR:O59156 (EMBL:AP000006) (249 aa) fasta scores: E(): 5e-23, 34.89% id in 235 aa.
  
 
 0.928
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.907
BP0104
Similar to Neisseria meningitidis hypothetical protein Nma1380 or Nmb1218 TR:Q9JRI4 (EMBL:AL162755) (91 aa) fasta scores: E(): 4.4e-11, 46.988% id in 83 aa, and to Escherichia coli hypothetical protein YbeD or B0631 or Z0776 or ECS0669 SW:YBED_ECOLI (P30977) (87 aa) fasta scores: E(): 4.4e-06, 38.554% id in 83 aa; Belongs to the UPF0250 family.
  
  
 0.727
nrdA
Putative pyruvate ferredoxin/flavodoxin oxidoreductase (pseudogene); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 
    0.673
lpdA
Similar to Escherichia coli dihydrolipoamide dehydrogenase LpdA or Lpd or B0116 SW:DLDH_ECOLI (P00391) (473 aa) fasta scores: E(): 4.1e-94, 55.579% id in 466 aa, and to Salmonella enterica subspenterica serovar Typhimurium. dihydrolipoamide dehydrogenase Lpd TR:Q9ACP1 (EMBL:AJ297525) (475 aa) fasta scores: E(): 4.7e-94, 55.246% id in 467 aa.
 
  
 0.669
lpdA-2
Similar to Escherichia coli dihydrolipoamide dehydrogenase LpdA or Lpd or B0116 or Z0126 or ecs0120 SW:DLDH_ECOLI (P00391) (473 aa) fasta scores: E(): 7.8e-97, 63.713% id in 474 aa, and to Alcaligenes eutrophus dihydrolipoamide dehydrogenase PdhL TR:Q59099 (EMBL:U09865) (594 aa) fasta scores: E(): 4.8e-147, 75.541% id in 601 aa.
 
  
 0.659
gcvP
Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.637
pdhA
Putative pyruvate dehydrogenase E1 component, alpha subunit; Similar to Clostridium magnum TPP-dependent acetoin dehydrogenase alpha-subunit TR:Q46142 (EMBL:L31844) (326 aa) fasta scores: E(): 8.2e-48, 43.631% id in 314 aa, and to Pseudomonas aeruginosa probable dehydrogenase e1 component Pa4150 TR:Q9HWN1 (EMBL:AE004831) (324 aa) fasta scores: E(): 3.1e-48, 45.541% id in 314 aa.
 
   
 0.572
BP0628
Similar to Zea mays pyruvate dehydrogenase E1 beta subunit isoform 2 Pdh2 TR:Q9ZQY2 (EMBL:AF069909) (374 aa) fasta scores: E(): 4.3e-56, 47.077% id in 325 aa, and to Rhizobium loti acetoin dehydrogenase Mll3628 TR:Q98FT4 (EMBL:AP003002) (332 aa) fasta scores: E(): 3.5e-60, 51.713% id in 321 aa.
 
  
 0.535
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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