STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (980 aa)    
Predicted Functional Partners:
BP0884
Probable carboxylase; Similar to Methanococcus jannaschii pyruvate carboxylase subunit B PycB or Mj1231 SW:PYCB_METJA (Q58628) (567 aa) fasta scores: E(): 5.8e-52, 35.685% id in 482 aa, and to Pyrococcus horikoshii 571aa long hypothetical oxaloacetate decarboxylase alpha chain ph0834 TR:O58564 (EMBL:AP000003) (571 aa) fasta scores: E(): 3.8e-49, 38.073% id in 436 aa.
     
 0.968
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.939
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
   
 
 0.934
mdH
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 
 0.934
pykA
Pyruvate kinase; Similar to Escherichia coli pyruvate kinase II PykA or b1854 SW:KPY2_ECOLI (P21599) (479 aa) fasta scores: E(): 2.1e-96, 59.32% id in 477 aa.
   
 
 0.934
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
   
 
 0.868
BP1513
Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
    
 0.831
fmdA
Formamidase; Similar to Methylophilus methylotrophus formamidase FmdA SW:FMDA_METME (Q50228) (407 aa) fasta scores: E(): 2e-125, 71.53% id in 397 aa, and to Emericella nidulans formamidase FmdS TR:Q9C453 (EMBL:AF274009) (411 aa) fasta scores: E(): 2e-91, 53.56% id in 407 aa.
  
  
  0.828
gltA
Putative membrane protein (pseudogene); Signal peptide predicted for BP2356 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.447 between residues 33 and 34; Belongs to the citrate synthase family.
     
 0.822
purU-2
Putative formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
   
 
  0.819
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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