STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bhuROuter membrane heme receptor; Previously sequenced as Bordetella pertussis outer membrane heme receptor BhuR TR:AAK38153 (EMBL:AY032627) (149 aa) fasta scores: E(): 2.7e-49, 100.000% id in 149 aa. Similar to Rhizobium meliloti putative iron transport protein Smc02726 TR:CAC46967 (EMBL:AL591790) (743 aa) fasta scores: E(): 4.6e-37, 37.630% id in 768 aa. (845 aa)    
Predicted Functional Partners:
hurR
Heme uptake transmembrane sensor; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 1e-22, 32.459% id in 305 aa, and to Pseudomonas aeruginosa probable transmembrane sensor Pa1911 TR:Q9I2J3 (EMBL:AE004617) (316 aa) fasta scores: E(): 2.4e-32, 41.118% id in 304 aa.
 
  
 0.947
bhuT
Similar to Yersinia enterocolitica hemin binding protein HemT TR:P74979 (EMBL:X77867) (279 aa) fasta scores: E(): 8.2e-29, 37.638% id in 271 aa, and to Yersinia pestis hemin-binding periplasmic protein HmuT precursor SW:HMUT_YERPE (Q56991) (279 aa) fasta scores: E(): 9.4e-29, 37.638% id in 271 aa.
 
  
 0.924
bhuS
Similar to Yersinia pestis hemin transport protein HmuS SW:HMUS_YERPE (Q56990) (345 aa) fasta scores: E(): 1.1e-46, 42.486% id in 346 aa, and to Yersinia enterocolitica hemin transport protein HemS SW:HEMS_YEREN (P31517) (345 aa) fasta scores: E(): 1.2e-46, 43.413% id in 334 aa.
 
  
 0.913
bhuV
Putative ATP-binding component of hemin transport system; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
 
  
 0.904
hurI
Heme uptake regulator; Similar to Escherichia coli probable RNA polymerase sigma factor FecI or B4293 SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 1.2e-26, 50.649% id in 154 aa, and to Pseudomonas aeruginosa putative RNA polymerase sigma factor Pa1912 TR:Q9I2J2 (EMBL:AE004617) (168 aa) fasta scores: E(): 8.9e-31, 55.689% id in 167 aa. Also similar to BP1136, 46.875% identity in 160 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily.
 
  
 0.878
tonB
Siderophore-mediated iron transport protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.860
bhuU
Putative hemin permease; Similar to Yersinia enterocolitica hemin permease HemU TR:P74980 (EMBL:X77867) (334 aa) fasta scores: E(): 4.8e-47, 50.000% id in 286 aa, and to Yersinia pestis hemin transport system permease protein HmuU SW:HMUU_YERPE (Q56992) (334 aa) fasta scores: E(): 7.3e-47, 49.141% id in 291 aa. Also similar to BP3340, 40.256% identity (42.568% ungapped) in 313 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
  
 0.854
fecR
Putative signal transduction protein; Similar to Escherichia coli protein FecR or B4292 SW:FECR_ECOLI (P23485) (317 aa) fasta scores: E(): 5.3e-19, 32.17% id in 317 aa, and to Pseudomonas putida pupI and pupR genes PupR TR:Q52209 (EMBL:X77918) (324 aa) fasta scores: E(): 1.3e-28, 37.88% id in 322 aa.
 
  
 0.807
BP3003
Putative membrane protein; Similar to Pseudomonas aeruginosa hypothetical protein PA0406 TR:Q9I698 (EMBL:AE004477) (319 aa) fasta scores: E(): 7.2e-18, 31.63% id in 294 aa.
  
 
 0.766
bfrG
Putative TonB-dependent receptor; Similar to Pseudomonas aeruginosa hypothetical protein Pa0434 TR:Q9I683 (EMBL:AE004480) (730 aa) fasta scores: E(): 7.2e-136, 49.52% id in 737 aa, and to Escherichia coli ferrichrome-iron receptor precursor FhuA or TonA or b0150 SW:FHUA_ECOLI (P06971) (747 aa) fasta scores: E(): 3.7e-14, 22.9% id in 786 aa.
  
  
 0.725
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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