STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyaABifunctional hemolysin-adenylate cyclase precursor; This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function; In the C-terminal section; belongs to the RTX prokaryotic toxin family. (1706 aa)    
Predicted Functional Partners:
cyaB
Cyclolysin secretion ATP-binding protein; Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family.
 
  
 0.992
cyaC
Cyclolysin-activating lysine-acyltransferase; Involved in fatty acylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP; Belongs to the RTX toxin acyltransferase family.
 
 
 0.991
cyaD
Cyclolysin secretion protein; CyaD is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
  
 0.977
prn
Pertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.
   
  
 0.964
cyaE
Cyclolysin secretion protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
  
  
 0.954
cpdA-2
Conserved hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
 
  
 0.940
cpdA
Putative cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
    
 0.932
sphB1
Previously sequenced as Bordetella pertussis autotransporter subtilisin-like protease SphB1 TR:CAC44081 (EMBL:AJ318229) (1039 aa) fasta scores: E(): 0, 100.000% id in 932 aa, and dimilar to Xylella fastidiosa serine protease Xf1026 TR:Q9PEK2 (EMBL:AE003939) (905 aa) fasta scores: E(): 1.1e-45, 31.919% id in 943 aa.
  
  
 0.922
tcfA
Tracheal colonization factor precursor; Identical to the previously sequenced Bordetella pertussis tracheal colonization factor precursor Tcfa2 TR:O86135 (EMBL:AJ009785) (647 aa) fasta scores: E(): 1.7e-171, 99.84% id in 647 aa.
   
  
 0.919
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.902
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.