STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyaBCyclolysin secretion ATP-binding protein; Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family. (712 aa)    
Predicted Functional Partners:
cyaD
Cyclolysin secretion protein; CyaD is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.999
cyaE
Cyclolysin secretion protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 
 0.999
cyaA
Bifunctional hemolysin-adenylate cyclase precursor; This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function; In the C-terminal section; belongs to the RTX prokaryotic toxin family.
 
  
 0.992
cyaC
Cyclolysin-activating lysine-acyltransferase; Involved in fatty acylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP; Belongs to the RTX toxin acyltransferase family.
 
  
 0.882
msbA
Putative ABC transporter; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
 
 
 
0.803
BP0872
Similar to Rhizobium loti ATP-binding protein of ABC transporter Mll0815 TR:Q98LY9 (EMBL:AP002995) (601 aa) fasta scores: E(): 3.1e-156, 74.624% id in 599 aa, and to Agrobacterium tumefaciens Agr_l_309p TR:AAK88722 (EMBL:AE008213) (600 aa) fasta scores: E(): 4.1e-147, 68.781% id in 599 aa.
 
 
 
0.795
BP2138
Similar to ABC-transporter ATP-binding components e.g. Vibrio cholerae putative toxin secretion transporter VC1446 TR:Q9KS15 (EMBL:AE004223) (721 aa) fasta scores: E(): 3.2e-44, 32.58% id in 577 aa.
 
 
 
0.784
BP2289
Putative outer membrane protein (pseudogene); (CTGGG)2 in pertussis; (CTGGG)1 in parapertussis and bronchiseptica.
  
 
 0.758
BP1743
ScanRegExp hit to PS00211, ABC transporters family signature. Confirmed by InterPro eMOTIF pattern match.
   
 
 0.757
prn
Pertactin precursor; Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.
   
    0.622
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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