STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyaECyclolysin secretion protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (474 aa)    
Predicted Functional Partners:
cyaB
Cyclolysin secretion ATP-binding protein; Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family.
 
 
 0.999
cyaD
Cyclolysin secretion protein; CyaD is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.999
BP2075
Putative efflux system inner membrane protein; Similar to e.g. Escherichia coli acriflavine resistance protein E precursor acrE or envC or b3265 SW:ACRE_ECOLI (P24180) (385 aa) fasta scores: E(): 1.4e-43, 47.684% id in 367 aa and Neisseria gonorrhoeae membrane fusion protein MtrC precursor mtrC SW:MTRC_NEIGO (P43505) (412 aa) fasta scores: E(): 2.5e-37, 41.304% id in 414 aa. Probably attached to inner membrane; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.964
cyaA
Bifunctional hemolysin-adenylate cyclase precursor; This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function; In the C-terminal section; belongs to the RTX prokaryotic toxin family.
  
  
 0.954
cusC
Similar to Escherichia coli probable outer membrane lipoprotein CusC precursor CusC or IbeB or B0572 SW:CUSC_ECOLI (P77211) (457 aa) fasta scores: E(): 4.9e-38, 39.655% id in 464 aa, and to Pseudomonas aeruginosa outer membrane protein OprM precursor OprM or OprK or Pa0427 SW:OPRM_PSEAE (Q51487) (485 aa) fasta scores: E(): 5.3e-67, 55.717% id in 481 aa.
  
 
 0.944
acrB
Acriflavine resistance protein a precursor (Pseudogene); Large deletion in pertussis relative to parapertussis and bronchiseptica following this codon.
 
 0.940
BP2076
Putative efflux system transmembrane protein; Similar to e.g. Escherichia coli acriflavine resistance protein B acrB or acrE or b0462 SW:ACRB_ECOLI (P31224) (1049 aa) fasta scores: E(): 3.1e-201, 52.073% id in 1037 aa and Neisseria gonorrhoeae rnd protein MtrD mtrD TR:Q51073 (EMBL:U60099) (1067 aa) fasta scores: E(): 3e-174, 51.873% id in 1068 aa.
 
 
 0.939
BP2289
Putative outer membrane protein (pseudogene); (CTGGG)2 in pertussis; (CTGGG)1 in parapertussis and bronchiseptica.
 
 
 0.786
cyaC
Cyclolysin-activating lysine-acyltransferase; Involved in fatty acylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP; Belongs to the RTX toxin acyltransferase family.
  
  
 0.752
ptlD
Putative membrane protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
   
  
 0.704
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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