STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (442 aa)    
Predicted Functional Partners:
aroC
Putative membrane protein (Pseudogene); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.997
tyrA
Similar to Bordetella bronchiseptica prephenate dehydrogenase TyrA TR:Q9RND8 (EMBL:AF182427) (299 aa) fasta scores: E(): 4.1e-108, 99.331% id in 299 aa, and to Rhizobium meliloti putative cyclohexadienyl dehydrogenase and adh prephenate dehydrogenase protein TR:CAC47240 (EMBL:AL591791) (307 aa) fasta scores: E(): 1.2e-33, 43.110% id in 283 aa.
 
  
 0.996
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.996
cmk
Cytidylate kinase; Similar to Escherichia coli cytidylate kinase Cmk or MssA or B0910 or Z1256 or Ecs0993 SW:KCY_ECOLI (P23863) (227 aa) fasta scores: E(): 8.1e-40, 57.674% id in 215 aa, and identical to Bordetella bronchiseptica cytidylate kinase Cmk SW:KCY_BORBR (Q9RND6) (223 aa) fasta scores: E(): 1.5e-79, 98.655% id in 223 aa.
 
  
 0.987
aroK
Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.978
pheA
Similar to Escherichia coli P-protein [includes: chorismate mutase and prephenate dehydratase] PheA or B2599 or Z3891 or Ecs3462 SW:PHEA_ECOLI (P07022) (386 aa) fasta scores: E(): 4.9e-27, 33.773% id in 379 aa, and to Neisseria meningitidis chorismate mutase/prephenate dehydratase nmb0446 TR:Q9K0W1 (EMBL:AE002401) (362 aa) fasta scores: E(): 3.3e-66, 50.276% id in 362 aa.
 
  
 0.952
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.946
BP3241
Putative chorismate-binding enzyme; Similar to Rhizobium loti Mlr3005 protein TR:Q98H70 (EMBL:AP003000) (381 aa) fasta scores: E(): 6.7e-44, 43.62% id in 353 aa, and to Klebsiella aerogenes para-aminobenzoate synthase component I PabB SW:PABB_KLEAE (P12679) (451 aa) fasta scores: E(): 1.6e-35, 45.03% id in 302 aa, and to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 4.5e-34, 40.49% id in 326 aa.
 
  
 0.895
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
  
 0.890
BP2318
Putative dehydratase; Similar to Amycolatopsis methanolica prephenate dehydratase PheA or Pdt SW:PHEA_AMYME (Q44104) (304 aa) fasta scores: E(): 3.1e-19, 35.76% id in 274 aa, and to Neisseria gonorrhoeae P-protein PheA SW:PHEA_NEIGO (Q9ZHY3) (362 aa) fasta scores: E(): 3.8e-17, 30.07% id in 266 aa.
 
  
 0.858
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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