STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BP0991Two-component response regulator; Similar to Bradyrhizobium japonicum transcriptional regulatory protein FixJ SW:FIXJ_BRAJA (P23221) (205 aa) fasta scores: E(): 3e-26, 41.146% id in 192 aa, and to Pseudomonas sp transcriptional activator StdR TR:O50213 (EMBL:AF031161) (207 aa) fasta scores: E(): 1.2e-27, 47.644% id in 191 aa. (208 aa)    
Predicted Functional Partners:
BP0992
Tw-component sensor kinase; Similar to Azorhizobium caulinodans sensor protein FixL SW:FIXL_AZOCA (P26489) (504 aa) fasta scores: E(): 1.7e-37, 47.893% id in 261 aa, and to Caulobacter crescentus sensory box histidine kinase FixL Cc0759 TR:Q9AA47 (EMBL:AE005751) (504 aa) fasta scores: E(): 2.4e-35, 45.059% id in 253 aa.
 
 
 0.981
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
    0.909
BP2004
Putative response regulator; Similar, except at N-terminus, to Pseudomonas aeruginosa type 4 fimbriae expression regulatory protein PilR, pilR or PA4547 SW:PILR_PSEAE (Q00934) (445 aa) fasta scores: E(): 2e-35, 40.123% id in 324 aa. Similar to many other bacterial response regulators.
  
 0.849
bvgS
Virulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals.
 
 
 0.729
BP1092
Probable two-component histidine kinase; Similar to Escherichia coli sensor protein KdpD or B0695 SW:KDPD_ECOLI (P21865) (894 aa) fasta scores: E(): 6.1e-11, 30.9% id in 233 aa, and to Pseudomonas aeruginosa hypothetical protein Pa1433 TR:Q9I3R4 (EMBL:AE004573) (650 aa) fasta scores: E(): 2.9e-27, 24.77% id in 654 aa.
  
   
 0.727
prlC
Similar to Escherichia coli oligopeptidase A PrlC or OpdA or B3498 SW:OPDA_ECOLI (P27298) (680 aa) fasta scores: E(): 7.2e-123, 46.009% id in 689 aa, and to Xylella fastidiosa oligopeptidase A Xf0127 TR:Q9PH19 (EMBL:AE003866) (674 aa) fasta scores: E(): 2.1e-134, 54.839% id in 682 aa.
       0.697
BP3350
Two component response regulator; Similar to Salmonella typhimurium transcriptional regulatory protein TctD TR:AAL21670 (EMBL:M28368) (224 aa) fasta scores: E(): 1.1e-37, 50.68% id in 219 aa, and to Ralstonia solanacearum putative response regulator transcription regulator protein RSC2935 TR:CAD16642 (EMBL:AL646072) (235 aa) fasta scores: E(): 2.8e-55, 66.36% id in 223 aa.
  
   
 0.596
BP2548
Similar to several two-component system, histidine kinases e.g. Rhizobium loti Mll7952 TR:Q984L4 (EMBL:AP003013) (452 aa) fasta scores: E(): 1.3e-44, 37.360% id in 447 aa and Salmonella typhi TctE TR:O68289 (EMBL:AF029846) (439 aa) fasta scores: E(): 1.2e-29, 32.576% id in 396 aa.
 
 
 
 0.584
BP3866
Two-component regulatory system family, sensor kinase protein. Similar to Burkholderia solanacearum putative transmembrane sensor kinase transcription regulator protein RSC2936 TR:CAD16643 (EMBL:AL646072) (500 aa) fasta scores: E(): 2e-59, 45.27% id in 466 aa, and to Pseudomonas aeruginosa probable two-component sensor PA0757 TR:Q9I5H2 (EMBL:AE004510) (460 aa) fasta scores: E(): 2.8e-41, 36.2% id in 453 aa.
 
 
 
 0.580
BP0988
Putative exported protein; Similar to Neisseria meningitidis putative lipoprotein Nma1767 TR:Q9JTI0 (EMBL:AL162757) (217 aa) fasta scores: E(): 1.6e-19, 39.490% id in 157 aa, and to Caulobacter crescentus Sco1/2 family protein Cc3503 TR:Q9A2Q3 (EMBL:AE006008) (190 aa) fasta scores: E(): 6.8e-18, 37.173% id in 191 aa.
       0.579
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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