STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tsr-2Similar to Escherichia coli methyl-accepting chemotaxis protein I Tsr or Ched or B4355 SW:MCP1_ECOLI (P02942) (551 aa) fasta scores: E(): 1.4e-54, 46.18% id in 550 aa, and to Escherichia coli methyl-accepting chemotaxis protein II Tar or Chem or B1886 SW:MCP2_ECOLI (P07017) (553 aa) fasta scores: E(): 1.3e-53, 45.24% id in 557 aa. (606 aa)    
Predicted Functional Partners:
cheA
Chemotaxis protein CheY (Pseudogene); HMMPfam hit to PF00072, Response regulator receiver domain.
 
 0.995
cheW
Similar to Escherichia coli chemotaxis protein CheW or B1887 or Z2941 or Ecs2597 SW:CHEW_ECOLI (P07365) (167 aa) fasta scores: E(): 1.3e-41, 74.83% id in 155 aa, and to Burkholderia pseudomallei (Pseudomonas pseudomallei) chemotaxis protein CheW TR:O05183 (EMBL:U92493) (175 aa) fasta scores: E(): 7e-43, 72.56% id in 164 aa.
 
 0.995
cheB
Chemotaxis protein methyltransferase (Pseudogene); Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.985
cheD
Conserved hypothetical protein; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
 
 0.980
cheY
Similar to Escherichia coli chemotaxis protein CheY or B1882 or Z2936 or Ecs2592 TR:AAG56872 (EMBL:K02175) (129 aa) fasta scores: E(): 5.1e-36, 78.73% id in 127 aa, and to Burkholderia pseudomallei (Pseudomonas pseudomallei) CheY TR:P94342 (EMBL:U78087) (131 aa) fasta scores: E(): 1.9e-37, 80.31% id in 127 aa.
 
 0.944
tar
Similar to Escherichia coli methyl-accepting chemotaxis protein II Tar or CheM or B1886 SW:MCP2_ECOLI (P07017) (553 aa) fasta scores: E(): 1.8e-64, 45.36% id in 529 aa, and to Escherichia coli methyl-accepting chemotaxis protein I Tsr or CheD or B4355 SW:MCP1_ECOLI (P02942) (551 aa) fasta scores: E(): 1.1e-62, 45.59% id in 522 aa.
 
   
0.943
tsr
Similar to Escherichia coli methyl-accepting chemotaxis protein I Tsr or CheD or B4355 SW:MCP1_ECOLI (P02942) (551 aa) fasta scores: E(): 3e-64, 46.71% id in 533 aa, and to Salmonella typhimurium methyl-accepting chemotaxis protein II TaR SW:MCP2_SALTY (P02941) (553 aa) fasta scores: E(): 1.2e-63, 45.87% id in 558 aa. Also similar to BP1384 (64.476% identity in 563 aa overlap), BP1385 (61.649% identity in 558 aa overlap), BP2268 (56.415% identity in 491 aa overlap), and to BP1591 (44.216% identity in 536 aa overlap).
  
 
 
0.904
flgK
Similar to Salmonella typhimurium flagellar hook-associated protein 1 FlgK or FlaS or FlaW SW:FLGK_SALTY (P15932) (552 aa) fasta scores: E(): 1.2e-68, 40.32% id in 558 aa, and to Escherichia coli flagellar hook-associated protein 1 FlgK or FlaS or FlaW or B1082 SW:FLGK_ECOLI (P33235) (546 aa) fasta scores: E(): 3.5e-70, 40.1% id in 551 aa.
 
 
 0.874
flgL
Flagellar hook-associated protein 3; Similar, over the N-terminal region, to Salmonella typhimurium flagellar hook-associated protein 3 FlgL or FlaT or FlaU SW:FLGL_SALTY (P16326) (317 aa) fasta scores: E(): 1.9e-21, 42.78% id in 194 aa, and to Pseudomonas aeruginosa flagellar hook-associated protein type 3 FlgL TR:Q9AGJ3 (EMBL:AF332547) (433 aa) fasta scores: E(): 2.4e-17, 28.29% id in 509 aa.
  
 
 0.856
bvgS
Virulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals.
  
 
 0.777
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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