STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glnDPutative multiple antibiotic resistance protein (Pseudogene); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and [...] (865 aa)    
Predicted Functional Partners:
glnB
Similar to many nitrogen regulatory proteins e.g. Rhodobacter sphaeroides P-II SW:GLNB_RHOSH () (112 aa) fasta scores: E(): 8.4e-31, 76.78% id in 112 aa; Belongs to the P(II) protein family.
 
 
 0.989
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.892
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.872
glnL
Similar to Escherichia coli nitrogen regulation protein NR(II) GlnL or NtrB or GlnR or B3869 or Z5405 or Ecs4791 SW:NTRB_ECOLI (P06712) (349 aa) fasta scores: E(): 2.4e-37, 41.42% id in 350 aa, and to Herbaspirillum seropedicae histidine kinase NtrB TR:O86056 (EMBL:AF082873) (364 aa) fasta scores: E(): 3e-55, 48.59% id in 356 aa.
  
 
 
 0.828
glnA
Similar to Escherichia coli glutamine synthetase GlnA or B3870 or Z5406 or Ecs4792 SW:GLNA_ECOLI (P06711) (468 aa) fasta scores: E(): 1.9e-129, 64.95% id in 468 aa, and to Herbaspirillum seropedicae glutamine synthetase GlnA TR:O86055 (EMBL:AF082873) (471 aa) fasta scores: E(): 1.6e-160, 81.5% id in 465 aa.
 
   
 0.762
dsbB
Similar to Escherichia coli disulfide bond formation protein B DsbB or RoxB or B1185 or Z1948 or Ecs1680 SW:DSBB_ECOLI (P30018) (176 aa) fasta scores: E(): 3.1e-05, 28.47% id in 144 aa, and to Pseudomonas aeruginosa disulfide bond formation protein B 1 DsbB1 or Pa5256 SW:DSB1_PSEAE (P21482) (163 aa) fasta scores: E(): 8.3e-08, 30.57% id in 157 aa.
  
    0.736
bamA
Probable surface antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.724
gltB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 8.3e-106, 44.45% id in 1597 aa, and to Deinococcus radiodurans glutamate synthase, large subunit DR0183 TR:Q9RXX2 (EMBL:AE001880) (1615 aa) fasta scores: E(): 0, 70.42% id in 1579 aa.
  
  
 0.722
rpsA
30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
  
   
 0.705
glnG
Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
      
 0.685
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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