STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (376 aa)    
Predicted Functional Partners:
ask
Aspartokinase; Similar to Mycobacterium smegmatis aspartokinase Ask SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 2e-66, 46.28% id in 417 aa, and to Ralstonia solanacearum probable aspartate kinase protein LysC TR:CAD14873 (EMBL:AL646063) (416 aa) fasta scores: E(): 3.7e-120, 77.34% id in 415 aa; Belongs to the aspartokinase family.
  
 
 0.994
BP2784
Similar to Pseudomonas aeruginosa homoserine dehydrogenase Hom or Pa3736 SW:DHOM_PSEAE (P29365) (434 aa) fasta scores: E(): 2.9e-97, 63.76% id in 436 aa.
 
 0.973
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
 
 0.964
BP0644
Similar to Thermotoga maritima dihydrodipicolinate synthase DapA or Tm1521 SW:DAPA_THEMA (Q9X1K9) (294 aa) fasta scores: E(): 8.1e-16, 28.400% id in 250 aa, and to Agrobacterium tumefaciens Agr_pat_671p TR:AAK90832 (EMBL:AE007915) (302 aa) fasta scores: E(): 6.3e-20, 32.056% id in 287 aa.
  
 
 0.938
BP3687
Similar to Nicotiana sylvestris dihydrodipicolinate synthase DHDPS-R1 TR:Q42940 (EMBL:X79060) (308 aa) fasta scores: E(): 4e-07, 26.61% id in 263 aa, and to Neisseria meningitidis dihydrodipicolinate synthase NMA1124 SW:DAPA_NEIMA (Q9JUU9) (291 aa) fasta scores: E(): 3.2e-13, 32.39% id in 284 aa; Belongs to the DapA family.
  
 
 0.938
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
  
  
 0.884
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
  
  
 0.878
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
  
  
 0.856
leuC-2
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.806
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
  
 0.767
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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