STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpFSimilar to Pseudomonas aeruginosa N-(5'-phosphoribosyl)anthranilate isomerase TrpF or Pa3113 SW:TRPF_PSEAE (Q59649) (211 aa) fasta scores: E(): 1.2e-28, 49.52% id in 210 aa, and to Acinetobacter calcoaceticus N-(5'-phosphoribosyl)anthranilate isomerase TrpF SW:TRPF_ACICA (P16923) (213 aa) fasta scores: E(): 1.4e-26, 44.9% id in 216 aa; Belongs to the TrpF family. (218 aa)    
Predicted Functional Partners:
trpC
Transposase (Pseudogene); Inverted repeat for IS481 element; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.998
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.996
trpG
Similar to Pseudomonas putida anthranilate synthase component II TrpG SW:TRPG_PSEPU (P00901) (198 aa) fasta scores: E(): 7.8e-46, 64.73% id in 190 aa.
  
 0.992
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.990
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.930
BP3241
Putative chorismate-binding enzyme; Similar to Rhizobium loti Mlr3005 protein TR:Q98H70 (EMBL:AP003000) (381 aa) fasta scores: E(): 6.7e-44, 43.62% id in 353 aa, and to Klebsiella aerogenes para-aminobenzoate synthase component I PabB SW:PABB_KLEAE (P12679) (451 aa) fasta scores: E(): 1.6e-35, 45.03% id in 302 aa, and to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 4.5e-34, 40.49% id in 326 aa.
 
  
 0.915
BP3242
Conserved hypothetical protein; Similar to Rhizobium loti Mlr3007 protein TR:Q98H69 (EMBL:AP003000) (220 aa) fasta scores: E(): 4.6e-18, 36.71% id in 207 aa, and to Rhizobium meliloti hypothetical protein Smc04014 TR:CAC47377 (EMBL:AL591791) (208 aa) fasta scores: E(): 4.7e-17, 40.77% id in 206 aa.
  
  
 0.800
BP1489
Putative membrane protein; Similar to Rhizobium meliloti hypothetical transmembrane protein Smc04249 TR:CAC46498 (EMBL:AL591788) (597 aa) fasta scores: E(): 8.1e-127, 61.42% id in 560 aa, and to Rhizobium loti Mll5170 protein Mll5170 TR:Q98CF6 (EMBL:AP003005) (589 aa) fasta scores: E(): 2.5e-122, 61.38% id in 549 aa.
  
    0.799
BP1488
Putative membrane protein; Similar to Rhizobium meliloti hypothetical transmembrane protein Smc04248 TR:CAC46497 (EMBL:AL591788) (191 aa) fasta scores: E(): 6.9e-34, 53.48% id in 172 aa, and to Rhizobium loti Mll5171 protein TR:Q98CF5 (EMBL:AP003005) (194 aa) fasta scores: E(): 3.9e-34, 50.78% id in 191 aa. Almost identical to BP0596, 99.522% identity in 209 aa overlap.
  
    0.784
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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