STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bvgSVirulence sensor protein; Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals. (1238 aa)    
Predicted Functional Partners:
bvgA
Virulence factors transcription regulator; Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.
 
 0.999
bvgR
Regulatory protein BvgR; Previously sequenced as Bordetella pertussis BvgR TR:O85677 (EMBL:AF071567) (291 aa) fasta scores: E(): 5.1e-121, 100% id in 291 aa.
  
 
 0.994
BP0745
Putative transcriptional regulator; Similar to Neisseria cinerea BasR TR:Q9F9Y4 (EMBL:AF139614) (222 aa) fasta scores: E(): 0.17, 28.729% id in 181 aa, and to Bordetella pertussis transcriptional regulatory protein, putative BasR TR:Q9S3M3 (EMBL:AJ132741) (223 aa) fasta scores: E(): 0.0027, 28.319% id in 226 aa.
  
 
 0.992
BP2074
Putative DNA-binding protein; Similar to the C-termini of two-component response regulators e.g. Rhodobacter sphaeroides DmsR dmsR TR:O32479 (EMBL:D89075) (232 aa) fasta scores: E(): 1.9e-05, 36.842% id in 114 aa. Possibly a pseudogene.
  
 
 0.992
cheA
Chemotaxis protein CheY (Pseudogene); HMMPfam hit to PF00072, Response regulator receiver domain.
  
 
 0.989
BP0992
Tw-component sensor kinase; Similar to Azorhizobium caulinodans sensor protein FixL SW:FIXL_AZOCA (P26489) (504 aa) fasta scores: E(): 1.7e-37, 47.893% id in 261 aa, and to Caulobacter crescentus sensory box histidine kinase FixL Cc0759 TR:Q9AA47 (EMBL:AE005751) (504 aa) fasta scores: E(): 2.4e-35, 45.059% id in 253 aa.
  
 
0.986
cheW
Similar to Escherichia coli chemotaxis protein CheW or B1887 or Z2941 or Ecs2597 SW:CHEW_ECOLI (P07365) (167 aa) fasta scores: E(): 1.3e-41, 74.83% id in 155 aa, and to Burkholderia pseudomallei (Pseudomonas pseudomallei) chemotaxis protein CheW TR:O05183 (EMBL:U92493) (175 aa) fasta scores: E(): 7e-43, 72.56% id in 164 aa.
  
 
 0.975
fliM
Similar to Escherichia coli flagellar motor switch protein FliM or Fla AII or Fla QII or CheC2 or B1945 SW:FLIM_ECOLI (P06974) (334 aa) fasta scores: E(): 3.6e-66, 52.32% id in 323 aa, and to Salmonella typhimurium flagellar motor switch protein FliM or Fla AII or Fla QII or CheC2 SW:FLIM_SALTY (P26418) (334 aa) fasta scores: E(): 1.6e-67, 52.96% id in 321 aa.
  
 
 0.975
ompR
Hypothetical protein (Pseudogene); Pseudogene. This CDS is disrupted by the insertion of IS481 element. No significant database matches.
 
 
 0.973
kdpE
Similar to Escherichia coli Kdp operon (involved in potassium transport) transcriptional regulatory protein KdpE or b0694 SW:KDPE_ECOLI (P21866) (225 aa) fasta scores: E(): 2.9e-54, 63.8% id in 221 aa and to Escherichia coli O157:H7 EDL933 regulator of Kdp operon KdpE TR:AAG55015 (EMBL:AE005247) (225 aa) fasta scores: E(): 4.5e-54, 63.34% id in 221 aa.
 
 
 0.966
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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