STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdHMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)    
Predicted Functional Partners:
gltA
Putative membrane protein (pseudogene); Signal peptide predicted for BP2356 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.447 between residues 33 and 34; Belongs to the citrate synthase family.
  
 0.993
BP1352
Putative exported protein (pseudogene); Signal peptide predicted for BP1351 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.996 between residues 17 and 18.
  
 0.988
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.974
maeB-2
Similar to Escherichia coli NADP-dependent malic enzyme MaeB or B2463 SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 8.6e-184, 62.13% id in 758 aa, and to Pasteurella multocida Mdh Mdh_1 or pm0002 TR:Q9CPN5 (EMBL:AE006034) (758 aa) fasta scores: E(): 5.8e-179, 62.48% id in 757 aa.
  
 0.966
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
   
 0.966
maeB-3
Similar to Escherichia coli NADP-dependent malic enzyme MaeB SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 1.6e-175, 60.07% id in 759 aa, and to Rhizobium meliloti NAD-dependent malic enzyme Dme SW:MAO1_RHIME (O30807) (770 aa) fasta scores: E(): 3.4e-169, 58.49% id in 759 aa.
  
 0.965
BP0884
Probable carboxylase; Similar to Methanococcus jannaschii pyruvate carboxylase subunit B PycB or Mj1231 SW:PYCB_METJA (Q58628) (567 aa) fasta scores: E(): 5.8e-52, 35.685% id in 482 aa, and to Pyrococcus horikoshii 571aa long hypothetical oxaloacetate decarboxylase alpha chain ph0834 TR:O58564 (EMBL:AP000003) (571 aa) fasta scores: E(): 3.8e-49, 38.073% id in 436 aa.
    
 0.939
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
   
 
 0.934
icd
Similar to Escherichia coli isocitrate dehydrogenase [NADP] Icd or IcdA or IcdE or b1136 SW:IDH_ECOLI (P08200) (416 aa) fasta scores: E(): 4.7e-116, 71.91% id in 413 aa, and to Pseudomonas aeruginosa isocitrate dehydrogenase icd or pa2623 TR:Q9I0L5 (EMBL:AE004691) (418 aa) fasta scores: E(): 5.3e-123, 76.31% id in 418 aa.
  
 
 0.925
prpC
Probable methylisocitrate lyase (pseudogene); (C)4 inpertussis; (C)2 in parapertussis and bronchiseptica; Belongs to the citrate synthase family.
  
 
 0.923
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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